Synthesis and Characterizations of Ethyl (2z) - 2 - (aryl) - 5 - (4-methoxyphenyl)- 7 -methyl - 3 - oxo-2, 3, 8, 8a-tetrahydro-5h- [1,3] thiozolo [3,2-a] pyrimidine-6-carboxylate as Biological Active Agents

Authors

  • Dr. B. B. Baldaniya  Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
  • J. S. Makwana  Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India

Keywords:

Thiozolo Pyrimidine, Antibacterial Activity, Biginelli Reaction.

Abstract

Pyrimidine plays a significant role among other heterocycles. Literature survey reveals that partially reduced pyridine and Pyrimidine derivatives are known to have antihypertensive property. Pyrimidine nucleus was synthesized by Biginelli reaction. The purpose of this study was to synthesize several title compounds (2a-2k) evaluate them for their antibacterial activity. The structures of all title compounds have been confirmed on the basis of their analytical, IR spectral data. The title compounds have been tested for antibacterial activities against different strains of bacteria.

References

  1. G. C. Rovnyak, S. D. Kimbali, B. Beyer, G. Cucinotta, J. D. Dimarco, J. Hedberg, M. Malley, J. P. McCarthy, R. Zhang and S. Moorland, J. Med. Chem.,1995, 38, 119.
  2. Biginelli, P. Ber. 1891, 24, 1317-2962.
  3. Kappe, C. O. Tetrahedron 1993, 49, 6937-6963. (Review)
  4. Hu, E. H.; Sidler, D. R.; Dolling, U.-H. J. Org. Chem. 1998, 63, 3453-3457.
  5. Wipf, P.; Cunningham, A. Tetrahedron Lett. 1995, 36, 7819-7822.
  6. Kappe, C. O. Bioorg. Med. Chem. Lett. 2000, 10, 49-51.
  7. Rovnyak, G. C.; Atwal, K. S.; Hedberg, A.; Kimball, S. D.; Moreland, S.; Gougoutas, J. Z.; O'Reilly, B. C.; Schwartz, J.; Malley, M. F. J. Med. Chem. 1992, 35, 3254-3263.
  8. Folkers, K.; Johnson, T. B. J. Am. Chem. Soc. 1933, 55, 3784-3791.
  9. C.o. kappe, acc. Chem. Res. 2002, 33,879.
  10. C.o. kappe, g. Uray, p. Verdino, o.v. shishkin, tetrahedron, 2000, 65, 1859.
  11. B.b. snider, z. Shi, j. Org. Chem,1993, 58,3228.
  12. V. Klusa, drugs fut,1995, 20,135.
  13. M. M Jotani, and B. B. Baldaniya, Acta Cryst., 2006, E62, o5871.
  14. M. M Jotani, and B. B. Baldaniya, Acta Cryst., 2007, E63, o1937.
  15. N. C. Desai,M. T. Chhabaria, Amit Dodiya, Ajit M. Bhavsar, B. B. Baldaniya, Synthesis, characterization, anticancer activity, and QSAR-studies of some new tetrahydropyrimidines, Med Chem Res (2011) 20:1331-1339.

International Journal of Scientific Research in Chemistry

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Published

2016-10-30

Issue

Volume 1, Issue 1, September-October-2016

Section

Research Articles

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How to Cite

[1]
Dr. B. B. Baldaniya, J. S. Makwana, " Synthesis and Characterizations of Ethyl (2z) - 2 - (aryl) - 5 - (4-methoxyphenyl)- 7 -methyl - 3 - oxo-2, 3, 8, 8a-tetrahydro-5h- [1,3] thiozolo [3,2-a] pyrimidine-6-carboxylate as Biological Active Agents, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 1, Issue 1, pp.07-11, September-October-2016.