Synthesis and Characterizations of Ethyl (2z) - 2 - (aryl) - 5 - (4-methoxyphenyl)- 7 -methyl - 3 - oxo-2, 3, 8, 8a-tetrahydro-5h- [1,3] thiozolo [3,2-a] pyrimidine-6-carboxylate as Biological Active Agents

Authors(2) :-J. S. Makwana, Dr. B. B. Baldaniya

Pyrimidine plays a significant role among other heterocycles. Literature survey reveals that partially reduced pyridine and Pyrimidine derivatives are known to have antihypertensive property. Pyrimidine nucleus was synthesized by Biginelli reaction. The purpose of this study was to synthesize several title compounds (2a-2k) evaluate them for their antibacterial activity. The structures of all title compounds have been confirmed on the basis of their analytical, IR spectral data. The title compounds have been tested for antibacterial activities against different strains of bacteria.

Authors and Affiliations

J. S. Makwana
Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
Dr. B. B. Baldaniya
Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India

Thiozolo Pyrimidine, Antibacterial Activity, Biginelli Reaction.

  1. G. C. Rovnyak, S. D. Kimbali, B. Beyer, G. Cucinotta, J. D. Dimarco, J. Hedberg, M. Malley, J. P. McCarthy, R. Zhang and S. Moorland, J. Med. Chem.,1995, 38, 119.
  2. Biginelli, P. Ber. 1891, 24, 1317-2962.
  3. Kappe, C. O. Tetrahedron 1993, 49, 6937-6963. (Review)
  4. Hu, E. H.; Sidler, D. R.; Dolling, U.-H. J. Org. Chem. 1998, 63, 3453-3457.
  5. Wipf, P.; Cunningham, A. Tetrahedron Lett. 1995, 36, 7819-7822.
  6. Kappe, C. O. Bioorg. Med. Chem. Lett. 2000, 10, 49-51.
  7. Rovnyak, G. C.; Atwal, K. S.; Hedberg, A.; Kimball, S. D.; Moreland, S.; Gougoutas, J. Z.; O'Reilly, B. C.; Schwartz, J.; Malley, M. F. J. Med. Chem. 1992, 35, 3254-3263.
  8. Folkers, K.; Johnson, T. B. J. Am. Chem. Soc. 1933, 55, 3784-3791.
  9. C.o. kappe, acc. Chem. Res. 2002, 33,879.
  10. C.o. kappe, g. Uray, p. Verdino, o.v. shishkin, tetrahedron, 2000, 65, 1859.
  11. B.b. snider, z. Shi, j. Org. Chem,1993, 58,3228.
  12. V. Klusa, drugs fut,1995, 20,135.
  13. M. M Jotani, and B. B. Baldaniya, Acta Cryst., 2006, E62, o5871.
  14. M. M Jotani, and B. B. Baldaniya, Acta Cryst., 2007, E63, o1937.
  15. N. C. Desai,M. T. Chhabaria, Amit Dodiya, Ajit M. Bhavsar, B. B. Baldaniya, Synthesis, characterization, anticancer activity, and QSAR-studies of some new tetrahydropyrimidines, Med Chem Res (2011) 20:1331-1339.

Publication Details

Published in : Volume 1 | Issue 1 | September-October 2016
Date of Publication : 2016-10-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 07-11
Manuscript Number : CH16112
Date Written : 2016-09-15
Publisher : Technoscience Academy

ISSN : 2456-8457

Suggested Citation :

J. S. Makwana, Dr. B. B. Baldaniya, "Synthesis and Characterizations of Ethyl (2z) - 2 - (aryl) - 5 - (4-methoxyphenyl)- 7 -methyl - 3 - oxo-2, 3, 8, 8a-tetrahydro-5h- [1,3] thiozolo [3,2-a] pyrimidine-6-carboxylate as Biological Active Agents", International Journal of Scientific Research in Chemistry (IJSRCH), ISSN : 2456-8457, Volume 1, Issue 1, pp.07-11, September-October.2016
URL : http://ijsrch.com/CH16112

Latest Tweets

Contact Us

Follow Us