Synthesis and Characterizations of Triazine Derivative - N2, N4-bis (6-bromo-1,3-benzothiazol-2-yl) - N6 - aryl - 1, 3, 5-triazine-2, 4, 6-triamine, derivative of 2, 4, 6-trimethyl-1, 3, 5-triazine as Biological Potent Agents

Authors(2) :-Hitendra N. Patel, Dr. B. B. Baldaniya

A series of N2,N4-bis(6-bromo-1,3-benzothiazol-2-yl)-N6-aryl-1,3,5-triazine-2,4,6-triamine 2a-k indole fused triazine derivatives have been synthesized by reaction between cyanuric chloride and benzothiazole. Product characterized by elemental and spectral analysis like IR and NMR.Further the compounds have been screened for antimicrobial activity against ten strains of Gram (+) and Gram (-) bacteria.

Authors and Affiliations

Hitendra N. Patel
Department of Chemistry, Shri Jagdishprasad Jhabarmal Tibrewala University, Vidhyanagari, Jhunjhunu, Rajashthan, India
Dr. B. B. Baldaniya
Department of Chemistry, M. G. Science Institute, Navarangpura, Ahmedabad, Gujarat, India

Triazine, Antibacterial Activity.

  1. Solankee A, and Kapadia K Synthesis and studies of some novel s- triazine basedaminopyrimidines, isoxazoles and 1,5 benzothiazepines. Indian journal of chemistry, 2007; 46B:1707-1712.
  2. Baldaniya B. B. and Patel P K, Synthesis Antibacterial and Antifungal Activities of s-Triazine Derivatives. E- Journal of Chemistry. 2009; 6(3): 673-680.
  3. Settimo F.D. and Primofiore G. 3-Aryl [1, 2, 4] triazino [4, 3-a] benzimidazol-4(10H)-ones: A new class of selective A1 adenosine receptor antagonists. J. Med.Chem. 2001; 44, 316-327.
  4. Palanki M. S. S. and Akiyama H. Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy) phenyl] amino} 1, 2, 4-benzotriazin-7-yl) phenyl benzoate (TG!100801): A topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. J. Med.Chem. 2008; 51, 1546-1559.
  5. MakhloufAbdelmoneim A. and MakladYousreya A. Synthesis and analgesic- antiinflammatory activities of some 1, 2, 4-triazine derivatives, Arzneimittel-Forschung, 2004; 54(1): 42-49.
  6. El-Gendy Z. and Morsy J. M. Synthesis of heterobicyclic nitrogen systems bearing a 1,2,4-triazine moiety as anticancer drugs: part iv. Phosphorus, Sulfur, and Silicon, 2003; 178: 2055-2071.
  7. Sztanke K. and Pasternak K. Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives. Europ. J. of medi. Chem, 2008; 43: 1085-1094.
  8. Mallikarjuna B. P. and Suresh Kumar G. V. Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines. J. Zhejiang UnivSci B. 2007; 8(7): 526-532.
  9. Sztanke K. and Pasternak K. Antibacterial action of novel 8-aryl-4-imino- 2, 3, 7, 8-tetrahydroimidazo [2,1-c][1, 2, 4] triazin- 3 (6H)-one derivatives. AnnalesUniversitatismariaecurie - S k łodowska Lublin - Polonia. 2007; LXII.
  10. Modzelewska-Banachiewicz B. and Kowalski C. Biological activity of 1,2,4-triazineand 1,2,4-triazole derivatives., Annalesuniversitatismariae curie - skłodowskalublin - polonia. 2007;LXII.
  11. Sztanke K. and Fidecka S. Antinociceptive activity of new imidazolidine carbonyl derivatives. Part 4. synthesis and pharmacological activity of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo[2,1-c][1,2,4]triazines. Europ. J. of Medi. Chem. 2005; 40: 127-134.
  12. Diana P. and Barraja P. Pyrrolo[2,1-c][1,2,4]triazines from 2-diazopyrroles: synthesis and antiproliferative activity. Europ. J. Medi.Chem. 2002; 37: 267-272.
  13. Costanzo A, Guerrini G, Benzodiazepine receptor ligands.7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide. 3-(2- Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents., Journal Med Chem., 2002, 45(26), 5710-20.
  14. Hunt J T and Mitt T, Discovery of the pyrrolo[2,1-f][1,2,4]Triazine nucleus as a new Kinase inhibitor template., Journal Med.Chem., 2004, 47, 4054-4059.
  15. Costanzo A and Guerrini G, Benzodiazepine Receptor Ligands. 4. synthesis and pharmacological evaluation of 3-heteroaryl-8- chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides., Journal Med.Chem., 1999, 42, 2218-2226.
  16. Hoque M. M. and Islam M. R. Cytotoxicity study of some indophenines and isatin derivatives. Bangladesh J. Pharmacol. 2008;3: 21-26.
  17. Abadi A. H. and Abou-Seri S. M. Synthesis of 3-substituted-2 oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents. Europ. J. Medi. Chem. 2006; 41: 296-305.
  18. George S. and Parameswaran M. K. Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives. Acta Pharm. 2008; 58: 119-129.
  19. Ravichandran V. and Mohan S. Synthesis and antimicrobial activity of Mannich bases of isatin and its derivatives with 2-[(2,6-dichlorophenyl)amino]phenyl acetic acid. Arkivoc. 2007; 14: 51-57.
  20. Aanandhi M. V. and George S. Synthesis and antimicrobial activities of 1-(5-substituted-2-oxoindolin-3-ylidene)-4-(substituted pyridin-2-yl)thiosemicarbazide. Arkivoc. 2008; 9; 187-194.
  21. Patel A. and Sanjay Bari S., Synthesis and Antimicrobial Activity of Some New Isatin Derivatives. Indian J. Pharm. Research. 2006; 4:249-254.
  22. Sriram D. and Bal T. R. Aminopyrimidiniminoisatin analogues: Design of novel nonnucleoside HIV-1 reverse transcriptase inhibitors with broadspectrum Chemotherapeutic properties. J. Pharm. Pharmaceut. Sci. 2005; 8(3):565-577.
  23. Jarrahpour A. and Khalili D. Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives. Molecules. 2007: 12: 1720-1730.
  24. Muthukumar V. A. and George S. Synthesis and Pharmacological Evaluation of 1-(1-((Substituted)methyl)-5-methyl-2-oxoindolin-3-ylidene)-4-(substitutedpyridin-2-yl) thiosemicarbazide. Biol. Pharm.Bull. 2008; 31(7): 1461-1464.
  25. Verma M. and Pandeya S. N. Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharm. 2004; 54: 49-56.
  26. Smitha S. and Pandeya S. N. Anticonvulsant and Sedative-Hypnotic Activities of N-Acetyl / Methyl Isatin Derivatives. Sci. Pharm. 2008; 76: 621-636.
  27. Desai N.C., Parikh A.R.; Indian J Exptl Biol.; 34, 584-587, 1996.
  28. National Committee for Clinical Laboratory Standard. Reference method for broth dilution antifungal susceptibility testing of yeasts Approved standard M27A. 1997, NCCLS, Wayne, PA.
  29. Organic synthesis; Collective vol.3; Noland, Wayland E., Editor in-chief; John Wiley & Sons. Inc. New York, 76, 1962.
  30. Desai N C, Dipika Dave, Shah M.D.and Vyas G.D., Indian J Chem, 39B, 2000, 277.
  31. Baldaniya B. B., Synthesis and Characterizations of N 2 -(Aryl)-N 4 , N 6 -bis (6, 7-dichloro-1, 3-benzothiazol-2-yl)-1, 3, 5-triazine-2, 4, 6-triamines as Biological Potent Agents. E- Journal of Chemistry. 2010, 7(1), 210-214.

Publication Details

Published in : Volume 1 | Issue 1 | September-October 2016
Date of Publication : 2016-10-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 18-22
Manuscript Number : CH16114
Date Written : 2016-09-20
Publisher : Technoscience Academy

ISSN : 2456-8457

Suggested Citation :

Hitendra N. Patel, Dr. B. B. Baldaniya, "Synthesis and Characterizations of Triazine Derivative - N2, N4-bis (6-bromo-1,3-benzothiazol-2-yl) - N6 - aryl - 1, 3, 5-triazine-2, 4, 6-triamine, derivative of 2, 4, 6-trimethyl-1, 3, 5-triazine as Biological Potent Agents ", International Journal of Scientific Research in Chemistry (IJSRCH), ISSN : 2456-8457, Volume 1, Issue 1, pp.18-22, September-October.2016
URL : http://ijsrch.com/CH16114

Latest Tweets

Contact Us

Follow Us