Manuscript Number : CH16119
Synthesis and Characterizations of N2,N4-bis(5-nitro-1,3-benzothiazol-2-yl)-N6-aryl-1,3,5-triazine-2,4,6-triamine,as Biological Agents
Authors(2) :-J. S. Makwana, Dr. B.B.Baldaniya
Some novel N2,N4-bis(5-nitro-1,3-benzothiazol-2-yl)-N6-aryl-1,3,5-triazine-2,4,6-triamine 1a-1l have been synthesized and characterized by elemental analyses IR and NMR spectra. The products tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria. Introduction of –OH, -NO2, -Cl and –Br groups to the heterocyclic frame work enhanced antibacterial activities
J. S. Makwana
Chemistry department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
Dr. B.B.Baldaniya
Chemistry department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
1, 3, 5-triazine-2, 4, 6-triamines; Antibacterial activity;
- Serullas A; Ann. Chim Phys.; 38, 379, 1828.
- Liebig J; Pogg. Ann. 15, 359 1829.
- Modest E J; Elderfied R C; "Heterocyclic Compounds", Wiley, New York; 7, 1 1961.
- Banks C. K.,Gruhza O.M., Tillitson E.W., John controulis.; J Am Chem Soc; 66; 1771, 1944.
- Zollinger H; Angew Chem; 73, 132, 1961.
- Dudley J R; J Am Chem Soc, 73, 2990, 1951.
- Dighade S R, Patil S D, Chincholkar M M & Dighade N R, Asian J Chem,15(2), 1184, 2003.
- Anjani Solankee & Indrajit Thakor, Ind J of Chem; 45B, 517, 2006.
- Solanki A and Patel J; Ind J of Chem, Vol. 43B; pp.1580, 2004.
- Desai K. R., Patel R.B., Desai P.S., Chikhalia K.H..; J Ind Chem Soc.;Vol.80; Pp-138, 2003.
- Curd F H S; J Chem Soc, 343, 1946.
- Lanalia N A, Thaker K A; J Ind Chem Soc, 59(9),1099-1101, 1982.
- Cetin, A. Cansiz, M. Digrak, Heteroatom Chem. 19 (4) 345–347, 2003.
- L. Xu, Y. Huang, G. Yu, G. Si, Q. Zhu, J. Struct. Chem. 17 (2) 235–239, 2006.
- M.S. Yar, A.A. Siddiqui, M.A. Ali, J. Serb. Chem. Soc. 72 (1) 5–11, 2007.
- S. D’Andrea, Z.B. Zheng, K. Denbleyker, J.C. Fung-Tomc, H. Yang, J. Clark, D. Taylor, J. Bronson, Bioorg. Med. Chem. Lett. 15, 2834-2839, 2005.
- S. Gafner, J.-L. Wolfender, S. Mavi, K. Hostettman, Planta Med. 62 (1) 67–69, 1996.
- S.F. McCann, G.D. Annis, R. Shapiro, D.W. Piotrowski, G.P. Lahm, J.K. Long, K.C. Lee, M.M. Hughes, B.J. Myers, S.M. Griswold, B.M. Reeves,R.W. March, P.L. Sharp, P. Lowder, W.E. Barnette, K.D. Wing, Pest. Manag. Sci. 57,153–164, 2001.
- H. Kawazura, Y. Takahashi, Y. Shiga, F. Shimada, N. Ohto, A. Tamura, Jpn. J. Pharmacol. 73 (4) 317–324, 1997.
- E. Palaska, M. Aytemir, I.T. Uzbay, D. Erol, Eur. J. Med. Chem. 36 (6) 539–543, 2001.
- Y.R. Prasad, A.L. Rao, L. Prasoona, K. Murali, P.R. Kumar, Bioorg. Med. Chem. Lett. 15,5030–5034,2005.
- National Committee for Clinical Laboratory Standard. Reference method for broth dilution antifungal susceptibility testing of yeasts Approved standard M27A. 1997, NCCLS, Wayne, PA.
- Organic synthesis; Collective vol.3; Noland, Wayland E., Editor in-chief; John Wiley & Sons. Inc. New York, 76, 1962.
- Desai N C, Dipika Dave, Shah M.D.and Vyas G.D., Indian J Chem, 39B, 2000, 277.
- Baldaniya B. B., Synthesis and Characterizations of N 2 -(Aryl)-N 4 , N 6 -bis (6, 7-dichloro-1, 3-benzothiazol-2-yl)-1, 3, 5-triazine-2, 4, 6-triamines as Biological Potent Agents. E- Journal of Chemistry. 7(1), 210-214, 2010.
- Baldaniya B. B. and Patel P K, Synthesis Antibacterial and Antifungal Activities of s-Triazine Derivatives. E- Journal of Chemistry. 6(3): 673-680, 2009.
Publication Details
Published in : Volume 1 | Issue 1 | September-October 2016
Date of Publication : 2016-10-30
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 35-38
Manuscript Number : CH16119
Date Written : 2016-09-24
Publisher : Technoscience Academy
URL : https://ijsrch.com/CH16119
Article Preview