Synthesis, Antimicrobial Activity and Characterization of Some Novel Thiozolo Pyrimidine Derivatives

Authors(2) :-J. S. Makwana, B. B. Baldaniya

Thirteen new thiozolo pyrimidine derivatives have been synthesized from Biginelli reaction. The structures of derivatives were established on the basis of their elemental analysis, IR, NMR and Mass Spectral data. The title compounds have been tested for antibacterial and antifungal activities against different strains of bacteria.

Authors and Affiliations

J. S. Makwana
Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
B. B. Baldaniya
Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India

Thiozolo Pyrimidine, Antibacterial Activity, Antifungal Activities, Biginelli Reaction

  1. V. Tomar, G. Bhattacharjee, Kamaluddina, A. Kumar, Synthesis and antimicrobial evolution of new Chalcones containing piperazine or 2,5-dichlorothiophene moiety. Bioorg Med Chem Lett. 2007; 17, 5321-4.
  2. Y. R. Prasad, P. R. Kumar, J. Smiles, P. A. Babu, QSAR studies on chalcone derivatives as antibacterial agents against Bacillus Pumilis, Arkivic. 2008; 11, 266-76.
  3. J. N. Dominguez, C. Leon, J. Rodrigues, N. G. Dominguez, J. Gut, P. J. Rosenthal, synthesis and antimalarial activity of sulfonamide chalcone derivatives, Farmaco. 2005; 60, 307-11.
  4. B. B. Baldaniya, M. M. Jotani, (2Z)-Ethyl2-(3-methoxy-4-acetyloxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro- 5H-1, 3 thiazolo-[3, 2-a]pyrimidine-6-carboxylate. Indian J. Phys, 2010, 84 (9) 1177-1182.
  5. R. Kalirajan, S. U. Sivakumar, S. Jubie, B. Gowramma, B. Suresh, synthesis and biological evaluation of some heterocyclic derivatives of Chalcones., int J Chem Res., 2009, 1, 27-34.
  6. B. B. Baldaniya, N.C. Desai., M.T.Chhabaria., Amit Dodia and Ajit M. Bhavsar, Synthesis characterization, anticancer activity and QSAR- studies of some new tetrahydropyrimidines, European journal medicinal chemistry, Med.Che.Res, (2011) 20:1331–1339, medicinal chemistry research, DOI: 10.1007/s00044-010-9481-4.
  7. V. R. Gadhachanda, B. Wu, Z. Wang, K. L. Kuhen, J. Caldwell, H. Zondler, et al., 4-amino-pyrimidines as novel HIV-1 inhibitors., Bioorg Med Chem Lett., 2007, 17, 260-5.
  8. A. Agarwal, K. Srivastava, S. K. Puri, PMS Chauhana, antimalarial activity and synthesis of new trisubstituted pyrimidines., Bioorg Med Chem Lett., 2005; 15, 3130-2.
  9. M. T. Chhabria, H. G. Bhatt, H. G. Raval, P. M. Oza, synthesis and biological evaluation of some 5-ethoxycarbonyl-6-isopropylamino-4-(substitutedphenyl)aminopyrimidines as potent analgesic and anti-inflammatory agents., Bioorg Med Chem Lett., 2007, 17, 1022-4.
  10. B. B. Baldaniya, M. M. Jotani., Ethyl (2Z) 2-(2-chlorobenzylidene)-7 methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thiazolo [3,2-a] pyrimidine-6-carboxylate. Acta Cryst., 2007, E-63, o1937- o1939, ISSN 1600-5368.
  11. N. V. Desai, A. M. Bhavsar, B. B. Baldaniya, synthesis and antimicrobial activity of 5-imidazolinone derivatives, Indian J Pharm Sci. 2009, 71, 90-4.
  12. A. Solankee, S. Solankee, G. Patel., potential antibacterial agents; 5-imidazolones derivatives., Rasayan J Chem., 2008, 1, 228-31.
  13. T El-Sayed Ali, S Abdel-Aghfaar Abdel-Aziz, H Metwali El-Shaaer, F Ismail Hanafy, A Zaky El-Fauomy., synthesis of some new 4-oxo-4H-chromene derivatives Bearing Nitrogen Heterocyclic synthesis as antifungal agents., Turk J Chem., 2008, 32, 365-74.

Publication Details

Published in : Volume 3 | Issue 1 | January-February 2018
Date of Publication : 2018-05-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 23-33
Manuscript Number : IJSRCH183304
Date Written : 2018-05-30
Publisher : Technoscience Academy

ISSN : 2456-8457

Suggested Citation :

J. S. Makwana, B. B. Baldaniya, "Synthesis, Antimicrobial Activity and Characterization of Some Novel Thiozolo Pyrimidine Derivatives", International Journal of Scientific Research in Chemistry (IJSRCH), ISSN : 2456-8457, Volume 3, Issue 1, pp.23-33, January-February.2018
URL : https://ijsrch.com/IJSRCH183304

Article Preview

Contact Us

  • Address : 3 & 4, Sterling Plaza, Indira Circle, 150 Feet Ring Road, Rajkot-360005, Gujarat, India