Manuscript Number : IJSRCH183324
Studies, Synthesis and Antimicrobial Activity of 6-Methyl-4-(3-Phenyl-Prridine-4-Yl-Methanone-1-H-Pyrazoyl )-2-Thio-N-Substituted Phenyl Pyrimide-5-Carboxamide.
Authors(2) :-Rathod. Chetan. C, Solanki . Manish. J.
Pyrimidine derivatives are most useful compounds among all the heterocyclic compounds for medicines and other various applications. Some newer pyrimidine derivatives eg. 6-methyl-4-(3-phenyl-pyridin-4-yl-methanone-1-H-pyrazol)-2-thio-N-substituted phenyl pyrimide-5-carboxamide (III a-j) have been synthesized by one pot synthesis from 3-phenyl-1-(pyridin-4-ylcarbonyl)-1-H-pyrazole-4-carbaldehyde, substituted aceto- acetanilide and urea/thiourea in acidic medium. The reactions were carried out based on well known name reaction Biginelli reaction (Aldehyde, diketo compound and urea/ thiourea).The synthesized compounds (III a-j) have been purified by column chromatography and characterized by spectroscopic technique like IR, 1H NMR and mass spectroscopy. Preparation methods for preparation of newer aldehyde 3-phenyl-1-(pyridin-4-ylcarbonyl)-1H-pyrazole-4-carbaldehyde newer dihydropyridine derivatives (III a-j) and Solvent system/ methods for the column chromatography have been discussed in this paper with physical properties of compounds compounds (III a-j).
Rathod. Chetan. C
Research Scholar, M.G. Science Institute, Ahmedabad, Gujarat, India and Shri Jagdishprasad Jhabarmal Tibrewal University
Solanki . Manish. J.
Department of Chemistry, C. U. Shah Science College, Ahmedabad, Gujarat, India
Publication Details
Published in : Volume 3 | Issue 3 | January-February 2018
Date of Publication : 2018-02-26
License: This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 15
Manuscript Number : IJSRCH183324
Date Written : 2018-02-26
Publisher : Technoscience Academy
URL : https://ijsrch.com/IJSRCH183324
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