Synthesis and Characterizations of Oxazolo Pyrimidine Derivatives as Biological Active and Antiinfective Agents

Authors

  • Dr. B. B. Baldaniya  Department of Chemistry, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
  • S. N. Chadotra  Department of Chemistry, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India

Keywords:

Oxazolo Pyrimidine, Antibacterial Activity, Biginelli Reaction.

Abstract

Pyrimidines are those molecules that make our life possible being the building blocks of DNA and RNA. Pyrimidine plays a significant role among other heterocycles. Literature survey reveals that partially reduced pyridine and Pyrimidine derivatives are known to have antihypertensive property. Pyrimidine nucleus was synthesized by Biginelli reaction. The aim of this study was to synthesize and introduse many title compound (1a -1m) evaluate them for their antibacterial and antifungal activity. The structures of all title compounds have been confirmed on the basis of their analytical, IR and NMR spectral data. The title compounds have been tested for antibacterial activities against different strains of bacteria.

References

  1. G. C. Rovnyak, S. D. Kimbali, B. Beyer, G. Cucinotta, J. D. Dimarco, J. Hedberg, M. Malley, J. P. McCarthy, R. Zhang and S. Moorland, J. Med. Chem.,1995, 38, 119.
  2. M. Zamadar(a); D. Aebisher; A. Greer "Singlet Oxygen Delivery Though the Porous Cap of a Hollow-Core Fiber Optic Device" J. Phys. Chem. B 2009.
  3. Biginelli, P. Ber. 1891, 24, 1317 & 2962.
  4. Kappe, C. O. Tetrahedron 1993, 49, 6937-6963. (Review)
  5. Hu, E. H.; Sidler, D. R.; Dolling, U.-H. J. Org. Chem. 1998, 63, 3453-3457.
  6. Wipf, P.; Cunningham, A. Tetrahedron Lett. 1995, 36, 7819-7822.
  7. M. Zamadar(a); A. Greer "Singlet Oxygen as an Reagent in Organic Synthesis" In Handbook of Synthetic Photochemistry; Albini, A., Fagnoni, M., Eds.; Wiley-VCH: Weinheim (in press).
  8. A. Castillo;(a); A. Greer "Theoretical Studies of a Singlet Oxygen-Releasing Dioxapaddlane (1,4-Diicosa naphthalene-1,4-endoperoxide)" Struct. Chem. 2009, 30, 399-407.
  9. M. L. Raber; A. Castillo;(a); A. Greer; C. A. Townsend "A Conserved Lysine in beta-Lactam Synthetase Assists Ring Cyclization: Implications for Clavam and Carbapenem Biosynthesis” ChemBioChem 2009 (submitted).
  10. E. M. Greer; D. Aebisher; A. Greer; R. Bentley "Computational Studies of the Tropone Natural Products, Thiotropocin, Tropodithietic acid, and Troposulfenin. Significance of Thiocarbonyl-enol Tautomerism” J. Org. Chem. 2008, 73, 280-283.
  11. A. Greer and J. F. Liebman "Paradigms and Paradoxes: Energetics of the Oxidative Cleavage of Azo Compounds” Struct. Chem. 2008, 19, 817-818.
  12. M. M Jotani and B. B. Baldaniya, Acta Cryst., 2006, E62, o5871-o5873.
  13. M. M Jotani and B. B. Baldaniya, Acta Cryst., 2007, E63, o1937-o1939.
  14. N. C. Desai,M. T. Chhabaria, Amit Dodiya, Ajit M. Bhavsar, B. B. Baldaniya, Synthesis, characterization, anticancer activity, and QSAR-studies of some new tetrahydropyrimidines, Med Chem Res, 2011,20:1331–1339.

International Journal of Scientific Research in Chemistry

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Published

2016-12-30

Issue

Volume 1, Issue 2, -2016

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Dr. B. B. Baldaniya, S. N. Chadotra, " Synthesis and Characterizations of Oxazolo Pyrimidine Derivatives as Biological Active and Antiinfective Agents, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 1, Issue 2, pp.01-06, -2016.