Green And Catalyst Free Synthesis of Some New Benzo[4,5]Imidazo[1,2-A]Pyrimidine Derivatives as Antimicrobial And Antitubercular Agents”

Abstract

There are several methods for the synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives has been reported. However, many of these methods suffered from harsh reaction condition, toxic reagents, strong acidic or basic conditions, prolonged reaction-times, poor yields and low selectivity. Several modifications have been made to counter these problems. Herein we have synthesized new series of 4-(1H-Imidazol-4-yl)-2-(substituted phenyl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidines under the frame of ‘green chemistry’. In the present study PEG 400 used as an alternative and green reaction solvent at first step and n-butanol at second step. The structures of synthesized compounds have been confirmed by spectral analysis, such as Mass, IR, 1HNMR and 13CNMR. All the synthesized compounds were screened for in vitro antimicrobial and antitubercular activity. The benzo[4,5]imidazo[1,2-a]pyrimidine derivatives with a pharmacologically potent group discussed in this poster may provide valued therapeutic important in the treatment of microbial and tubercular diseases.