Metal Complex Affects Enzyme Activates

Abstract

Coordination compounds can also affect some enzyme activities. We know that small molecules are able to selectively inhibiting a particular enzyme, which are usually organic compounds. Controlling enzyme activity by coordination compounds plays an important role in discovering new inorganic drug candidates [19]. Furthermore, the advantage that metal-binding compounds and metal complexes can provide such kind of unique properties contributing to enzyme inhibition that are not found in conventional in conventional organic molecules [20]. The mechanisms that how they control the enzyme activity varies from different complexes. Some compounds directly bind to the active side of the enzyme and blocking access of the substrate to the enzyme. In contrast to those binding directly to active site, some complexes bind to the non active site of substrate or enzyme, changing their conformation in order to prevent the correct binding of substrate to enzyme. Other enzyme itself contains coordination structure and functions the catalysis. There are many other kinds of mechanisms as well but in this article we mainly talk about the following examples.