Molecular Properties Prediction and Synthesis of Novel Benzimidazole Analogues as Potent Antimicrobial agents

Authors

  • Akshay R. Yadav  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
  • Dr. Shrinivas K. Mohite   Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India

Keywords:

Benzimidazole, Antimicrobial agents, Molecular properties prediction, Lipinski ‘Rule of five’

Abstract

In the present investigation, a series of benzimidazole derivative were subjected to molecular properties prediction, druglikeness by Molinspiration (Molinspiration, 2008) and MolSoft (MolSoft, 2007) software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski ‘Rule of five’ were synthesized for antimicrobial screening as oral bioavailable drugs/leads. Maximum drug-likeness model score (0.71) was found for compound, 2b. All the synthesized compounds were characterized by IR, NMR and mass spectral analysis followed by antimicrobial screening. Among all the title compound, 2b showed maximum activity against all bacterial strains comparable to standard drug ciprofloxacin, while the compounds, 2b and 2d showed maximum antifungal activity than standard drug fluconazole.

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International Journal of Scientific Research in Chemistry

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Published

2019-12-30

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Volume 4, Issue 6, November-December-2019

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Research Articles

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[1]
Akshay R. Yadav, Dr. Shrinivas K. Mohite , " Molecular Properties Prediction and Synthesis of Novel Benzimidazole Analogues as Potent Antimicrobial agents, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 4, Issue 6, pp.23-34, November-December-2019.