Recent Advances in Manufacturing Technologies and Future Prospects of Mouth Dissolving Tablets (FDTs)

Authors

  • Kiran R. Salunkhe  Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Ghogaon, India-415111
  • Akshay R. Yadav   Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist-Sangli, Maharashtra, India-415404

Keywords:

Mouth dissolving tablets, Zydis technology, Wow tab technology, Oraquick technology, Future prospects

Abstract

Due to the increasing demand of novel drug delivery, the fast disintegrating drug delivery system has become one of the mile stone in the novel drug delivery system. The introduction of fast dissolving drug delivery system has encountered the delivery of conventional dosage form. Recent advances in the formulation development and processing technologies meet the efforts to achieve more sophisticated drug delivery system. Mouth dissolving tablets need to be formulated for pediatric, geriatric, psychotic patients, bedridden and for those who are busy in travelling and may not have to assess to water. The drugs delivered in MDT’S may be absorbed in the pregastric sites of highly permeable buccal and mucosal tissues of the oral cavity and they may be suitable of low molecular weight and highly permeable drugs.

References

  1. Caramella C, Ferrari F, Bonferoni MC and Ronchi, M. Disintegrants in solid dosage forms. Drug Dev Ind Pharm 1990; 16:2561.
  2. Bagul Udhav S, Bagul Nitish S, Kulkarni Minal S, Dr Sawant SD, Dr Gujjar KN and Bidkar AA. Manufacturing technologies for mouth dissolving tablets.
  3. www.pharmainfo.net.
  4. Parakh SR and Gothoskar AV. A review of mouth dissolving tablet technologies. Pharm Tech 2003; 27(11):92?98.
  5. Nail SL and Gatlin LA. Freeze Drying: Principles and Practice, Parenteral Medications, in Pharmaceutical Dosage Forms. 2nd ed. Vol. 2. Marcel Dekker, New York; 1993:163.
  6. Kuchekar BS, Badhan CA and Mahajan HS. Mouth dissolving tablets: A novel drug delivery system. Pharma Times 2003; 35:7?10.
  7. Yarwood RJ, Kearny P and Thomson AR. Process for preparing solid pharmaceutical dosage forms. US Patent 1998; No. 5738875.
  8. Mizumoto T, Masuda Y and Fukui M. Intrabuccally dissolving compressed moldings and production process thereof. US Patent 1996; No. 5576014.
  9. Kaushik D, Dureja H and Saini TR. Mouth dissolving tablets: A Review. Indian Drugs 2004; 41(4):187?192.
  10. Gole DJ, Levinson RS and Carbone J. Preparation of pharmaceutical and other matrix systems by solid state dissolution. US Patent 1993; No. 5215756.
  11. Shangraw R, Mitrevej A and Shah M. A new era of tablet disintegrants. Pharm Technol 1980; 4(10):49?57.
  12. Dobeti L. Fast disintegrating tablets. PCT Patent 1999; No. 44580?Ai. Gohel M, Patel M, Amin A, Agrawal R, Dave R and Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech 2004; 5:36.
  13. Reddy LH, Ghosh B and Rajneesh. Fast dissolving drug delivery system: A review of literature. Indian J Pharm Sci 2002; 64 (4): 331?336.
  14. Habib W, Khankari R and Hontz J. Fast?dissolving drug delivery systems: Critical review in therapeutics. Drug Carrier Systems 2002; 17(1): 61?72.
  15. Bradoo R, Shahani S, Poojary S, Deewan, B and Sudarshan S. Fast dissolving drug delivery systems. JAMA India 2001; 4(10):27?31.
  16. Biradar SS, Bhagavati ST and Kuppasad IJ. Fast dissolving drug delivery systems: A brief overview. The Int J Pharmacol 2006; 4(2): 29-34.
  17. Bhaskaran S, Narmada GV. Rapid Dissolving tablet A Novel dosage form. Indian Pharmacist 2002; 1:9?12.
  18. Devrajan PV and Gore SP, Melt? in? mouth tablets: innovative oral drug delivery system. Express Pharma Pulse 2000; 7(1):16.
  19. Makino T, Yamada M, and Kikuta J. Fast dissolving tablet and it production. US Patent 1998; No. 5720974.
  20. Bolhius GK, Zuurman K and Te?Wierik GH. Improvement of dissolution of poorly soluble drugs by solid deposition on a super disintegrant. Part 2. Choice of super disintegrants and effect of granulation. Eur J Pharm Sci 1997; 5(2): 63–69.

International Journal of Scientific Research in Chemistry

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Published

2020-04-25

Issue

Volume 5, Issue 2, March-April-2020

Section

Research Articles

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How to Cite

[1]
Kiran R. Salunkhe, Akshay R. Yadav , " Recent Advances in Manufacturing Technologies and Future Prospects of Mouth Dissolving Tablets (FDTs), International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 5, Issue 2, pp.33-38, March-April-2020.