Toxicological Evaluation of Eclipta alba using Brine Shrimp (Artemia salina L.) Model

Authors

  • Akshay R.Yadav  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli, Maharashtra, India
  • Dr. Shrinivas K. Mohite  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli, Maharashtra, India

Keywords:

Eclipta alba, Brine shrimp lethality assay, Toxicity testing, Artemia salina

Abstract

Brine shrimp lethality assay is the most useful tool for tracking the biological behavior of different plant species. This method is useful in advance for the toxicity evaluation of plant extracts. Eclipta alba leaves have long been in use in the Indian Local Medicine System for their antioxidant and anti-inflammatory properties. The toxicity of Eclipta alba herb extracts using this assay was determined within a concentration range of 1mg/ml, 100μg/ml, 10μg/ml and 1μg/ml of the herbal extract being tested. Most studies of the toxicity with a Brine Shrimp lethality test measure toxicity after 24 hours of exposure to the examined sample. The Brine shrimp lethality assay is a perfect method for assessing the toxic potential of plant extracts.

References

  1. Heeks R. Health information systems: Failure, success and improvisation. Int J Med Inform. 2006; 75: 125–137.
  2. Boonstra A, Govers MJ. Understanding ERP system implementation in a hospital by analysing stakeholders. N Technol Work Employ. 2009; 24(2): 177–193.
  3. Keshavjee K, Bosomworth J, Copen J, Lai J, Kucukyazici B, Liani R, Holbrook AM. Proceed of the 11th International Symposium on Health Information Mangement Research – iSHIMR. 2006. Best practices in EMR implementation: a systematic review:. 1–15.
  4. McGinn CA, Grenier S, Duplantie J, Shaw N, Sicotte C, Mathieu L, Leduc Y, Legare F, Gagnon MP. Comparison of use groups perspectives of barriers and facilitator to implementing EHR – a systematic review. BMC Med. 2011; 9: 46.
  5. Pettigrew AM. Context and action in the transformation of the firm. J Manag Stud. 1987; 24(6): 649–670.
  6. Hartley J. Case Study Research. Chapter 26. In: Cassel C, Symon G, editors. Essential Guide to Qualitative Methods in Organizational Research. London: Sage; 2004.
  7. Hage E, Roo JP, Offenbeek MAG, Boonstra A. Implementation factors and their effect on e-health service adoption in rural communities: a systematic literature review. BMC Health Serv Res. 2013; 13(19): 1–16.
  8. ISO: Health informatics . Draft Tech Report. 2004. Electronic health record - Definition, scope and context: 03–16.
  9. Hayrinen K, Saranto K, Nykänen P. Definition, structure, content, use and impacts of electronic health records: A review of the research literature. Int J Med Inform. 2008; 77: 291–304.
  10. Kaushal R, Shojania KG, Bates DW. Effects of computerized physician order entry and clinical decision support systems on medication safety: a systematic review. Arch Intern Med. 2003; 163(12): 1409–1416.
  11. Weir C, Lincoln M, Roscoe D, Turner C, Moreshead G. Dimensions associated with successful implementation of a hospital based integrated order entry system. Proc Annu Symp Comput Appl Sic] in Med Care Symp Comput Appl Med Care. 1994; 653: 7
  12. Yadav A, Mohite S. A Novel approach for treatment of COVID-19 with Convalescent Plasma. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 227-230.
  13. Yadav A, Mohite S. A Review on Novel Coronavirus (COVID-19). International Journal of Pharma Sciences and Research. 2020; 11(5): 74-76.
  14. Yadav A, Mohite S. A Review on severe acute respiratory infection (SARI) and its clinical management in suspect/confirmed novel coronavirus (nCoV) cases Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 178-180.
  15. Aarts J, Doorewaard H, Berg M. Understanding implementation: The case of a computerized physician order entry system in a large dutch university medical center. J Am Med Inform Assoc. 2004; 11(3): 207–216.
  16. Aarts J, Berg M. Same systems, different outcomes - Comparing the implementation of computerized physician order entry in two Dutch hospitals. Methods Inf Med. 2006; 45(1): 53–61.
  17. Ash J, Gorman P, Lavelle M, Lyman J, Fournier L. Investigating physician order entry in the field: lessons learned in a multi-center study. Stud Health Technol Inform. 2001; 84(2): 1107–1111.
  18. Ash JS, Gorman PN, Lavelle M, Payne TH, Massaro TA, Frantz GL, Lyman JA. A cross-site qualitative study of physician order entry. J Am Med Inform Assoc. 2003; 10(2): 188–200.
  19. Boyer L, Samuelian J, Fieschi M, Lancon C. Implementing electronic medical records in a psychiatric hospital: A qualitative study. Int J Psychiatry Clin Pract. 2010;14(3):223–227.
  20. Cresswell KM, Worth A, Sheikh A. Integration of a nationally procured electronic health record system into user work practices. BMC Med Inform Decis Mak. 2012; 12: 15. 27.
  21. Ford EW, Menachemi N, Huerta TR, Yu F. Hospital IT Adoption Strategies Associated with Implementation Success: Implications for Achieving Meaningful Use. J Healthc Manag. 2010; 55(3): 175–188.
  22. Gastaldi L, Lettieri E, Corso M, Masella C. Performance improvement in hospitals: leveraging on knowledge assets dynamics through the introduction of an electronic medical record. Meas Bus Excell. 2012; 16(4): 14–30.
  23. Houser SH, Johnson LA. Perceptions regarding electronic health record implementation among health information management professionals in Alabama: a statewide survey and analysis. Perspect Health Inf Manage/AHIMA, Am Health Inf Manage Assoc. 2008; 5: 6–6.
  24. Jaana M, Ward MM, Bahensky JA. EMRs and Clinical IS Implementation in Hospitals: A Statewide Survey. J Rural Health. 2012; 28: 34–43.
  25. Katsma CP, Spil TAM, Ligt E, Wassenaar A. Implementation and use of an electronic health record: measuring relevance and participation in four hospitals. Int J Healthc Technol Manag. 2007;8(6):625–643.
  26. Ovretveit J, Scott T, Rundall TG, Shortell SM, Brommels M. Improving quality through effective implementation of information technology in healthcare. Int J Qual Health Care. 2007; 19(5): 259–266.
  27. Poon EG, Blumenthal D, Jaggi T, Honour MM, Bates DW, Kaushal R. Overcoming barriers to adopting and implementing computerized physician order entry systems in US hospitals. Health Aff. 2004; 23(4): 184–190.
  28. Rivard S, Lapointe L, Kappos A. An Organizational Culture-Based Theory of Clinical Information Systems Implementation in Hospitals. J Assoc Inf Syst. 2011; 12(2): 123–162.
  29. Scott JT, Rundall TG, Vogt TM, Hsu J. Kaiser Permanente’s experience of implementing an electronic medical record: a qualitative study. Br Med J. 2005; 331(7528): 1313–1316.
  30. Simon SR, Keohane CA, Amato M, Coffey M, Cadet M, Zimlichman E. Lessons learned from implementation of computerized provider order entry in 5 community hospitals: a qualitative study. BMC Med Inform Decis Mak. 2013; 13: 67.
  31. Takian A, Sheikh A, Barber N. We are bitter, but we are better off: case study of the implementation of an electronic health record system into a mental health hospital in England. BMC Health Serv Res. 2012; 12: 484.
  32. Ward MM, Vartak S, Schwichtenberg T, Wakefield DS. Nurses’ Perceptions of How Clinical Information System Implementation Affects Workflow and Patient Care. Cin-Comput Inform Nurs. 2011; 29(9): 502–511.
  33. Ward MM, Vartak S, Loes JL, O’Brien J, Mills TR, Halbesleben JRB, Wakefield DS. CAH Staff Perceptions of a Clinical Information System Implementation. Am J Manage Care. 2012; 18(5): 244–252.
  34. Yoon-Flannery K, Zandieh SO, Kuperman GJ, Langsam DJ, Hyman D, Kaushal R. A qualitative analysis of an electronic health record (EHR) implementation in an academic ambulatory setting. Inform Prim Care. 2008; 16(4): 277–284.
  35. Van Aken J, Berends H, Van der Bij H. Problem solving in organizations. New York, USA: Cambridge University Press; 2012.
  36. Botha ME. Theory development in perspective: the role of conceptual frameworks and models in theory development. J Adv Nurs. 1989; 14(1): 49–55.43.
  37. Spetz J, Keane D. Information Technology Implementation in a Rural Hospital: A Cautionary Tale. J Healthc Manag. 2009; 54(5): 337–347.
  38. Massaro TA. Introducing Physician Order Entry at a Major Academic Medical-Center. Impact Organ Culture Behav Acad Med. 1993; 68(1): 20–25.
  39. Kanter RM, Stein BA, Jick TD. The Challenge of Organizational Change. New York, USA: Free Press; 1992.
  40. Lundberg S, Bergman M. Tender evaluation and supplier selection methods in public procurement. J Purch Supply Manage. 2013; 19(2): 73–83.

International Journal of Scientific Research in Chemistry

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Published

2020-11-30

Issue

Volume 5, Issue 6, November-December-2020

Section

Research Articles

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How to Cite

[1]
Akshay R.Yadav, Dr. Shrinivas K. Mohite, " Toxicological Evaluation of Eclipta alba using Brine Shrimp (Artemia salina L.) Model, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 5, Issue 6, pp.56-62, November-December-2020.