Pathogensis of Cell Injury
Keywords:
Cell death, Tissue damage, Irreversible injury, PathogenesisAbstract
When cells are injured, one of two patterns will generally results in reversible cell injury leading to adaptation of the cells and tissue, or irreversible cell injury leading to cell death and tissue damage. When cells adapt to injury, their adaptive changes can be atrophy, hypertrophy, hyperplasia, or metaplasia. Injured cells may also accumulate materials including fat, cholesterol, protein, glycogen, or pigment. Cell membrane diseases are life threatning disorders which are genetic in nature. They usually work against proteins in the body which are important for ion channels and receptors within the membrane. Ribosomopathies can arise from abnormalities of either rRNA or varios RPs. Abnormal ribosome biogenesis is linked to several human genetic disease. Different diseases are discuss related to pathogenesis of reversible and irreversible injury. Mitochondrial diseases are caused by mutations in the mitochondrial DNA. At other times they are caused by mutations in genes of nuclear DNA whose gene products are imported into the mitochondria as well as acquired mitochondrial conditions understanding pathogenesis of injury aspects is foundational to the understanding of disease processes and conditions.
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