Imidazole : Having Versatile Biological Activities
Keywords:
Antibacterial Agents, Antifungal Agents, Imidazole, DrugAbstract
Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities, and are widely researched and applied by pharmaceutical companies for drug discovery. We synthesized, evaluated for their antibacterial and antifungal activities. All the target compounds showed strong antifungal and antibacterial activity. These results strongly suggest that some of the compounds produced in this work have value for development as Antimicrobial agents.
References
- Zheng, Xunan, Zhengning Ma, and Dawei Zhang. "Synthesis of imidazole-based medicinal molecules utilizing the van leusen imidazole synthesis." Pharmaceuticals 13.3 (2020): 37.
- Gaba, M., & Mohan, C. (2016). Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. Medicinal Chemistry Research, 25, 173-210.
- Liu, M., Jiang, Y., Liu, D., Wang, J., Ren, Z., Russell, T. P., & Liu, Y. (2021). Imidazole-functionalized imide interlayers for high performance organic solar cells. ACS Energy Letters, 6(9), 3228-3235.
- Tang, P., Ke, D., Shao, J., Chen, W., & Yu, Y. (2019). Synthesis of polyfunctional imidazoles from vinyl azides and amidine along with NHBoc as a leaving group. Tetrahedron, 75(33), 4419-4424.
- Harisha, M. B., Dhanalakshmi, P., Suresh, R., Kumar, R. R., Muthusubramanian, S., & Bhuvanesh, N. (2019). TMSOTf?Catalysed Synthesis of 2, 4, 5?Trisubstituted Imidazoles from Vinyl Azides and Nitriles. ChemistrySelect, 4(10), 2954-2958.
- Nikolaenkova, E. B., Tikhonov, A. Y., & Grishchenko, S. Y. (2019). Reactivity of oximes of 1-aryl (hetaryl)-2-(hydroxyamino) propan-1-ones with ethyl glyoxylate. Chemistry of Heterocyclic Compounds, 55, 142-146.
- Strelnikova, J. O., Rostovskii, N. V., Starova, G. L., Khlebnikov, A. F., & Novikov, M. S. (2018). Rh (II)-catalyzed transannulation of 1, 2, 4-oxadiazole derivatives with 1-sulfonyl-1, 2, 3-triazoles: Regioselective synthesis of 5-sulfonamidoimidazoles. The Journal of Organic Chemistry, 83(18), 11232-11244.
- Pardeshi, S. D., Sathe, P. A., Vadagaonkar, K. S., Melone, L., & Chaskar, A. C. (2018). Copper-Catalyzed Simultaneous Activation of C–H and N–H Bonds: Three-Component One-Pot Cascade Synthesis of Multisubstituted Imidazoles. Synthesis, 50(02), 361-370.
- Salfeena, C. T. F., Jalaja, R., Davis, R., Suresh, E., & Somappa, S. B. (2018). Synthesis of 1, 2, 4-Trisubstituted-(1 H)-imidazoles through Cu (OTf) 2-/I2-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines. ACS omega, 3(7), 8074-8082.
- Heravi, M. M., Bakhtiari, K., Oskooie, H. A., & Taheri, S. (2007). Synthesis of 2, 4, 5-triaryl-imidazoles catalyzed by NiCl2· 6H2O under heterogeneous system. Journal of Molecular Catalysis A: Chemical, 263(1-2), 279-281.
- Bahrami, K., Khodaei, M. M., & Nejati, A. (2011). One-pot synthesis of 1, 2, 4, 5-tetrasubstituted and 2, 4, 5-trisubstituted imidazoles by zinc oxide as efficient and reusable catalyst. Monatshefte für Chemie-Chemical Monthly, 142, 159-162.
- Nikoofar, K., Haghighi, M., Lashanizadegan, M., & Ahmadvand, Z. (2015). ZnO nanorods: efficient and reusable catalysts for the synthesis of substituted imidazoles in water. Journal of Taibah University for Science, 9(4), 570-578.
- Kaur, S., & Dhillon, G. S. (2014). The versatile biopolymer chitosan: potential sources, evaluation of extraction methods and applications. Critical reviews in microbiology, 40(2), 155-175.
- Dhillon, G. S., Kaur, S., Brar, S. K., & Verma, M. (2013). Green synthesis approach: extraction of chitosan from fungus mycelia. Critical reviews in biotechnology, 33(4), 379-403.
- Dodane, V., & Vilivalam, V. D. (1998). Pharmaceutical applications of chitosan. Pharmaceutical Science & Technology Today, 1(6), 246-253.
- Hirano, S., Seino, H., Akiyama, Y., & Nonaka, I. (1990). Chitosan: a biocompatible material for oral and intravenous administrations. Progress in biomedical polymers, 283-290.
- Elieh-Ali-Komi, D., & Hamblin, M. R. (2016). Chitin and chitosan: production and application of versatile biomedical nanomaterials. International journal of advanced research, 4(3), 411.
- Iber, B. T., Kasan, N. A., Torsabo, D., & Omuwa, J. W. (2022). A review of various sources of chitin and chitosan in nature. Journal of Renewable Materials, 10(4), 1097.
- Dash, M., Chiellini, F., Ottenbrite, R. M., & Chiellini, E. (2011). Chitosan—A versatile semi-synthetic polymer in biomedical applications. Progress in polymer science, 36(8), 981-1014.
- Slassi, S., Fix-Tailler, A., Larcher, G., Amine, A., & El-Ghayoury, A. (2019). Imidazole and azo-based schiff bases ligands as highly active antifungal and antioxidant components. Heteroatom Chemistry, 2019.
- A.W.Bauer,D.M.Perry,and Kirby,“Single-Disk Antibiotic-Sensitivity Testing of Staphylococci: An Analysis of Technique and Results”,AMA Arch Intern Med.,104,No.2,208–216,1959.
- P. K.Sahu, P. K. Sahu, S. K., Gupta, & D. D.Agarwal,Chitosan: An efficient, reusable, and biodegradable catalyst for green synthesis of heterocycles. Industrial & Engineering Chemistry Research,53,No.6,2085-2091,2014.
- Septiana, I., Purwono, B., Anwar, C., Nurohmah, B. A., & Syahri, J. (2022). Synthesis and Docking Study of 2–Aryl-4, 5-diphenyl-1 H-imidazole Derivatives as Lead Compounds for Antimalarial Agent. Indonesian Journal of Chemistry, 22(1), 105-113.
- Rajaraman, D., Sundararajan, G., Loganath, N. K., & Krishnasamy, K. J. J. O. (2017). Synthesis, molecular structure, DFT studies and antimicrobial activities of some novel 3-(1-(3, 4-dimethoxyphenethyl)-4, 5-diphenyl-1H-imidazol-2-yl)-1H-indole derivatives and its molecular docking studies. Journal of Molecular Structure, 1127, 597-610.
- Anthony, L. A., Nethaji, P., Sundararajan, G., & Rajaraman, D. (2022). One-pot synthesis, Spectral, X-ray crystal structure, Hirshfeld surface and computational study on potential inhibitory action of novel 1-benzyl-2-(4-methoxynaphthalen-1-yl)-4, 5-diphenyl-1H-imidazole derivatives against COVID-19 main protease (Mpro: 6WCF/6Y84). Journal of Molecular Structure, 1250, 131892.
- Kanawaade, P., Sharma, N., Pandhare, R., & Kanawade, M. P. A Review On: Imidazole Derivatives As A Multifunctional Moiety. European Journal of Molecular & Clinical Medicine, 10(01), 2023.
Downloads
Published
Issue
Section
License
Copyright (c) IJSRCH

This work is licensed under a Creative Commons Attribution 4.0 International License.