A Study of Synthesis, Characterization and Biological Activity of Schiff Bases

Authors

  • Dr. Rakesh Ranjan  M.Sc., Ph.D. , Chemistry, B.R.A. Bihar University, Muzaffarpur, Bihar, India

Keywords:

schiff bases; benzthiozol; aminophenol; antibacterial; antifungal.

Abstract

Three new series of biologically active amino substituted Schiff bases with general formula R1N=CHR2. Here R1 = 2-amino-benzthiazole, 4-amino-salicylic acid and 4-aminophenol. R2 =4-chloro-benzaldehyde, 2-chloro-benzaldehyde, salicylaldehyde, vanillin and benzaldehyde were synthesized by the reaction of three different amino substituted compounds and substituted aldehydes in ethanol. Such compounds were characterized by different physico-chemical techniques like, melting point, elemental analysis, multinuclear NMR (1H, 13C). The free ligands and their metal complexes have been screened for their in vitro biological activities against bacteria, fungi and yeast. The metal complexes show more potent activities compared with Schiff base ligands.

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International Journal of Scientific Research in Chemistry

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Published

2018-01-30

Issue

Volume 3, Issue 1, January-February-2018

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Dr. Rakesh Ranjan, " A Study of Synthesis, Characterization and Biological Activity of Schiff Bases , International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 3, Issue 1, pp.75-77, January-February-2018.