Synthesis of Some New Quinazoline Derivatives Incorporating Sydnone Moiety and Evaluation of Their Antimicrobial and Antitubercular Activities
Keywords:
Antimicrobial Activity, Mesoionic, Quinazoline, Sydnone.Abstract
In this study, we present the synthesis of a novel set of sydnone derivatives, specifically 3-(4-chlorophenyl)-4-N-[2-(substitutedphenyl)-4-oxoquinazoline-3(4H)-yl]sulfamoyl-sydnone 7a-i, derived from 3-(4-chlorophenyl)-4-(chlorosulfonyl) sydnone. The characterization of the recently synthesized compounds was conducted using infrared (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectrometry, and elemental analysis. A screening was conducted to evaluate the antibacterial activity of the synthesized compounds against Gram-positive bacteria such as S. aureus and S. pyogenes, as well as Gram-negative bacteria including E. coli and P. aeruginosa. Additionally, the compounds were assessed for their antifungal activity against C. albicans and A. niger.
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