Synthesis, Characterization and Biological Evaluation of Some Novel Theino Pyridine Derivatives

Authors

  • R. S. Dave  Shri U. P. Arts, Smt. M. G. Panchal Science and Shri V. L. Shah Commerce College, Pilvai, Gujarat, India
  • Vipul M. Vyas  Shri U. P. Arts, Smt. M. G. Panchal Science and Shri V. L. Shah Commerce College, Pilvai, Gujarat, India
  • Vipul J. Vyas  Shri U. P. Arts, Smt. M. G. Panchal Science and Shri V. L. Shah Commerce College, Pilvai, Gujarat, India
  • Abishek V Nandasana  M & N Virani Science College Rajkot, Gujarat, India

Keywords:

Synthesis, Characterization, Biological Evaluation, Pyridine Derivatives

Abstract

Pyridine and its derivatives have been observed intensively active biodynamically. Which is presented in this work. Pyridine derivatives have also been synthesized with the help of nucleophilic substitution reactions. The constitutions of the synthesized derivatives have been characterized with the help of Elemental analysis, IR, 1H NMR, 13C and MS. All the newly synthesized compounds were screened for antibacterial and antifungal activities (MIC) in vitro by both dilution method with two Gram positive bacteria (S. Aureus MTCC 96 and S. pyogenes MTCC 442), two Gram negative bacteria (E. Coli MTCC 443 and P. aeruginosa MTCC 1688) and fungi A. Niger MTCC 282.

References

  1. Maria C. S. Lourenço, Marcus V. N. de Souza, Alessandra C. Pinheiro, Marcelle de L. Ferreira, Raoni S. B. Gonçalves, Thais Cristina M. Nogueira, Monica A. Peraltab. Arkivoc, 2007; (xv): 181-191.
  2. De Clercq E. Nature Reviews Drug Discovery, 2006; 5 (12): 1015–1025. 3. O. P. Zhirnov. Virology, 1990; 176: 274–279.
  3. K. Martin, A. Helenius. Cell, 1991; 67: 117–130.
  4. R. A. Bright, D. K. Shay, B. Shu, N. J. Cox, A. I. Jama Klimov. J. Am. Med. Assoc., 2006; 295: 891–894.
  5. V. M. Deyde, X. Y. Xu, R. A. Bright, M. Shaw, C. B. Smith, Y. Zhang, Y. L. Shu, L. V. Gubareva, N. J. Cox, A. I. Klimov. J. Infect. Dis, 2007; 196: 249–257.
  6. Navin B. Patel, Suresh N. Agravat, Faiyazalam M. Shaikh. Med Chem Res, 2011; 20: 1033– 1041.
  7. Yeong Woo Jo, Weon Bin Im, Jae Keol Rhee, Mi Ja Shim, Won Bae Kim, Eung Chil Choi. Bioorganic & Medicinal Chemistry, 2004; 12: 5909–5915.
  8. Deepika Sharma, Balasubramanian Narasimhan, Pradeep Kumar, Abraham Jalbout. Eu- ropean Journal of Medicinal Chemistry, 2009; 44: 1119-1127.
  9. Rosy Pradhan, Manabendra Patra, Ajaya K. Behera, Bijay K. Mishra, Rajani K. Behera. Tetrahedron, 2006; 62: 779–828.
  10. (a) S. M. Weinreb, J. Auerbach, J. Am. Chem. Soc., 1975; 97: 2503-2507. (b) M. F. Semmelhack, B. P. Chong, R. D. Stauffer, T. D. Rogenson, A. Chong, L. D. Jones. J. Am. Chem. Soc., 1975; 97: 2507–2516.
  11. G. Lang, A. Pinkert, J. W. Blunt, M. H. G. Munro. J. Nat. Prod, 2005; 68: 1796–1798.
  12. G. P. Ellis. Chromenes, Chromanones and Chromones. In The Chemistry of Heterocyclic Compounds; Wiley: New York, 1977; 31: 11–139.
  13. J. M. Elliott, H. G. Selnick, D. A. Claremon, J. J. Baldwin, S. A. Buhrow, J. W. Butcher,
  14. C. N. Habecker, S. W. King, J. J. Lynch, B. T. Phillips, G. S. Ponticello, E. M. Radzil-owski,
  15. D. C. Remy, R. B. Stein, J. I. White, M. B. Young. J. Med. Chem, 1992; 35: 3973.
  16. T. Ishikawa, Y. Oku, T. Tanaka, T. Kumamoto. Tetrahedron Lett., 1999; 40: 3777-3780.

International Journal of Scientific Research in Chemistry

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Published

2020-11-30

Issue

Volume 5, Issue 6, November-December-2020

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
R. S. Dave, Vipul M. Vyas, Vipul J. Vyas, Abishek V Nandasana, " Synthesis, Characterization and Biological Evaluation of Some Novel Theino Pyridine Derivatives, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 5, Issue 6, pp.69-77, November-December-2020.