Pharmacognostic, Phytochemical Investigation and Antioxidant Potential of Embelia ribes

Authors

  • Nilesh J. Pawara  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, India
  • Akshay R. Yadav  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, India
  • Dr. Shrinivas K. Mohite  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, India

Keywords:

Embelia ribes, Pharmacognostic, Phytochemical, DPPH radical assay method, scavenging activity, Antioxidant activity.

Abstract

The recent global resurgence of interest in herbal medicines has led to an increase in the demand for them. In Indian system of medicine ‘Ayurveda’ Embelia ribes is popularly known as Vidanga. The present study was undertaken to investigate the pharmacognostical and phytochemical parameters of Embelia ribes. Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Embelia ribes have traditionally been used to manage several diseases such as rheumatism, diarrhea, diabetes mellitus, and cough. The results of the free radical scavenging activity of the DPPH radical assay method for antioxidant activity have shown that the Embelia ribes extract exhibits significant scavenging activity.

References

  1. Patwardhan A, Mhaskar M, Joglekar A, Tadwalkar T, Wagh R. Propagation and Cultivation Techniques of Embelia ribes (Vidanga). Daya Publishing House, New Delhi. 2014: 237-256.
  2. Mhaskar M, Joshi S, Chavan B, Jogleka A, Barve N. Status of Embelia ribes Burm. f. (Vidanga), an important medicinal species of commerce from northern Western Ghats of India. Curr Sci. 2011; 100: 547-552.
  3. Chaudhari AB (2007) Endangered Medicinal Plants. Daya Publishing House, Delhi.
  4. Poojari R. Embelin-a drug of antiquity: Shifting the paradigm towards modern medicine. Expt Opin Investig Drugs. 2014; 23: 427-444.
  5. Bhandari U, Jain N, Pillai KK. Further studies on antioxidant potential and protection of pancreatic β -cells by Embelia ribes in Experimental diabetes. Exp Diab Res. 2007; 7: 1-6.
  6. Harish GU, Danapur V, Jain R, Patel VM. Endangered Medicinal Plant Embelia ribes Burm. f.-A review. Phacog J. 2014; 4: 6-19.
  7. Asadulla S, Ramandang and Rajasekharan. Botanical Standardization of the Embeli Ribes Burm. f. and Possibilities of Species Substitute. Global J Med Res. 2013; 13: 31-34.
  8. Gupta S, Sanyal SN, Kanwar U. Antispermatogenic effect of embelin, a plant enzoquinone, on male albino rats in vivo and in vitro. Contraception. 1989; 39: 307-320.
  9. Nazish I, Ansari SH, Arora P (2012) Antiobesity actions of Embelia ribes. Phcog J 4: 73-80.
  10. Yadav A, Mohite S, Magdum C. Synthesis, Characterization and Biological Evaluation of Some Novel 1,3,4-Oxadiazole Derivatives as Potential Anticancer Agents. Int. j. sci. res. sci. technol. 2020; 7(2): 275-282.
  11. Yadav A, Mohite S. Anticancer Activity and In-Silico ADMET Analysis of Malvastrum Coromandelianum. International Journal of Pharma Sciences and Research. 2020; 11(5): 71-73.
  12. Yadav A, Mohite S. Cancer- A Silent Killer: An Overview. Asian J. Pharm. Res. 2020; 10(3): 213-216.
  13. Chitruk A, Yadav A, Rode P, Mohite S, Magdum C. Synthesis and toxicological evaluation using brine shrimp lethality assay of Novel 1,2,4-triazole derivatives with anticancer activity. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22877-22881.
  14. Yadav A, Mohite S. Design, Synthesis and Characterization of Some Novel benzamide derivatives and it’s Pharmacological Screening. Int. j. sci. res. sci. technol. 2020; 7(2): 68-74.
  15. Honmane P, Yadav A, Singh S, Mohite S. Microwave Assisted Synthesis of Novel Benzimidazole Derivatives as Potent Antileishmanial and Antimalarial Agents. Int. J. Curr. Adv. Res. 2020; 09(07)(B): 22742-22746.
  16. Yadav A, Mohite S. A Brief Review: Microwave Chemistry and its Applications. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 191-197.
  17. Chitruk A, Yadav A, Rode P, Mohite S, Magdum C. Microwave assisted synthesis, antimicrobial and anti-inflammatory potential of some novel 1,2,4-triazole derivatives. Int. j. sci. res. sci. technol. 2020; 7(4): 360-367.
  18. Yadav A, Mohite S. Antioxidant Activity of Malvastrum Coromandelianum Leaf extracts. Research J. Topical and Cosmetic Sci. 2020; 11(2): 71-72.
  19. Yadav A, Mohite S. In-Silico ADME Analysis of 1, 3, 4-oxadiazole derivatives as CDK9 Inhibitors. International Journal of Chemical Science. 2020; 4(3): 01-04
  20. Yadav A, Patil S, Dharanguttikar V, Mohite S. Anthelmintic Activity of Malvastrum Coromandelianum Leaf Extracts against Pheretima Posthuma and Ascardia Galli. International Journal of Scientific Research in Chemistry. 2020; 5(6): 18-24.
  21. Yadav A, Mohite S. Formulation and Evaluation of Antidandruff Shampoo. Research J. Topical and Cosmetic Sci. 2020; 11(2): 58-61.
  22. Yadav A, Mohite S, Magdum C. Comparative Study of Conventional and Microwave Assisted Synthesis of some Organic Reactions. Asian J. Pharm. Res. 2020; 10(3): 217-220.
  23. Yadav A, Mohite S. Different Techniques and Characterization of Polymorphism with their Evaluation: A Review. Asian J. Pharm. Tech. 2020; 10(3): 213-216.
  24. Yadav A, Mohite S. Aquasomes as a Self Assembling Nanobiopharmaceutical Carrier System for Bio-Active Molecules. Research J. Topical and Cosmetic Sci. 2020; 11(2): 66-70.
  25. Yadav A, Mohite S. Anthelmintic and Antibacterial Activity of Psidium Guajava Leaf Extracts. International Journal of Scientific Research in Chemistry. 2020; 5(6): 06-11.
  26. Yadav A, Dange V, Mohite S. Pathogensis of Cell Injury. International Journal of Scientific Research in Chemistry. 2020; 5(6): 12-18.
  27. Suryawanshi V, Yadav A, Birajdar R, Jagtap N, Vambhurkar G, Patil P. Optimization of ayurvedic herbal medicine by nanoformulation. Asian J. Res. Pharm. Sci. 2019; 9(1): 55-56.
  28. Yadav A, Honmane P, Bhosale M, Chitruk A, Rode P, Birajdar R, Rajput M, Suryawanshi V, Patil S, Patil, Jagtap N, Mohite S, Dange V, Vambhurkar G. Antifungal Activity of Malvastrum Coromandelianum Leaf Extracts. International Journal of Scientific Research in Chemistry. 2020; 5(6): 01-05.
  29. Yadav A, Mohite S. Potential Role of Peptides for Development of Cosmeceutical skin Product. Research J. Topical and Cosmetic Sci. 2020; 11(2): 79-84.
  30. Yadav A, Mohite S. Green Chemistry approach for Microwave assisted synthesis of some Traditional Reactions. Asian J. Research Chem. 2020; 13(4): 261-264.
  31. Yadav A, Mohite S. Screening of In-vitro anti-inflammatory and Antifungal assay of Psidium guajava Leaf Extracts. Research J. Topical and Cosmetic Sci. 2020; 11(2): 62-65.
  32. Yadav A, Mohite S, Magdum C. Microwave assisted synthesis of some Traditional reactions: Green chemistry approach. Asian J. Research Chem. 2020; 13(4): 275-278.
  33. Yadav A, Mohite S. Applications of Nanotechnology in Cosmeceuticals. Research J. Topical and Cosmetic Sci. 2020; 11(2): 73-78.
  34. Yadav A, Mohite S. Rajput M, Suryawanshi V, Birajdar R, Patil M. Antioxidant Activity of Psidium guajava Leaf Extracts. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 159-161.
  35. Yadav A, Mohite S. ADME analysis of phytochemical constituents of Psidium guajava. Asian J. Res. Chem. 2020; 13(5): 373-375.
  36. Rode P, Yadav A, Chitruk A, Mohite S, Magdum C. Synthesis, Anticancer and Molecular Docking Studies of N-(1H-benzimidazol-2-yl-carbamothioyl)benzamide Analogues. International Journal of Scientific Research in Science and Technology International Journal of Scientific Research in Chemistry. 2020; 5(6): 204-212.
  37. Yadav A, Mohite S. Recent advances in protein and peptide drug delivery. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 205-212.
  38. Yadav A, Mohite S. A Novel approach for treatment of COVID-19 with Convalescent Plasma. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 227-230.
  39. Yadav A, Mohite S. A Review on Novel Coronavirus (COVID-19). International Journal of Pharma Sciences and Research. 2020; 11(5): 74-76.
  40. Yadav A, Mohite S. A Review on severe acute respiratory infection (SARI) and its clinical management in suspect/confirmed novel coronavirus (nCoV) cases Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 178-180.
  41. Yadav A, Mohite S. A Review on Zika Virus Infection. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 245-249.
  42. Honmane P, Yadav A, Singh S, Mohite S. Formulation and Evaluation of Herbal Ointment Containing Eclipta Alba (L.) Extract. Seybold Rep. 2020; 25(10): 569-577.
  43. Yadav A, Mohite S. Toxic?logical Evaluation of Psidium guajava Leaf Extracts using Brine Shrimp (Artemia salina L.) Model. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 198-120.
  44. Honmane P, Yadav A, Singh S, Mohite S. Synthesis, Characterization and Antiplatelet Activity of Antithrombotic novel 2,5-substituted aryl-7-phenyl-1,3,4-oxadiazolo-3,2-a]-1,3,5-triazine Derivatives. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 881-898.
  45. Patil S, Yadav A, Chopade A, Mohite S. Design, Development and Evaluation of Herbal Mouthwash for Antibacterial Potency against Oral Bacteria. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 881-898.1137-1148.
  46. Yadav A, Mohite S. Homology Modeling and Generation of 3D-structure of Protein. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 218-224.
  47. Honmane P, Yadav A, Singh S, Mohite S. Synthesis of Pyrazole Acrylic acid based Oxadiazole and Amide Derivatives as Larvicidal and Antitubercular agents. Seybold Rep. 2020; 25(10): 516-530.
  48. Yadav A, Mohite S. Recent Advances in the Ultrasound-Assisted Synthesis of Oxadiazole and Thiazole Derivatives. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 225-228.
  49. Yadav A, Mohite S. An Overview on Ebola Virus Disease. Res. J. Pharma. Dosage Forms and Tech.2020; 12(4): 230-235.
  50. Yadav A, Mohite S. Carbon Nanotubes as an Effective Solution for Cancer Therapy. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(4): 238-241.
  51. Honmane P, Yadav A, Singh S, Mohite S. 3D printing technology in pharmaceuticals and biomedical. World J Pharm Pharm Sci. 2020; 9(9): 598-609
  52. Yadav A, Mohite S, Magdum C. Preparation and Evaluation of Antibacterial Herbal Mouthwash against Oral Pathogens. Asian J. Res. Pharm. Sci. 2020; 10(3): 149-152.
  53. Gavali K, Yadav A, Howal R, Tamboli A. Preliminary Phytochemical Screening and HPTLC Finger printing of Leaf Extracts of Tectona grandis Linn Journal of University of Shanghai for Science and Technology. 2020; 22(11): 1804-1815.
  54. Rajput M. D, Yadav A. R, Mohite S. K. Synthesis, Characterization of Benzimidazole Derivatives as Potent Antimicrobial Agents. International Journal of Pharmacy & Pharmaceutical Research. 2020; 17(4): 279-285.
  55. Dange V, Dinde S, Doiphode A, Dhavane S, Dudhal B, Shid S, Yadav A. Formulation and Evaluation of Herbal gel Containing Lantana Camara for Management of Acne Vulgaris. Journal of University of Shanghai for Science and Technology.2020; 22(11): 799-809.
  56. Yadav A, Mohite S. Screening of In-vitro anti-inflammatory and Antibacterial assay of Malvastrum Coromandelianum. International Journal of Pharma Sciences and Research. 2020; 11(4): 68-70.
  57. Rajput M, Yadav A. Green Chemistry Approach for Synthesis of Some 1,3,4-Oxadiazole Derivatives As Potent Antimalarial Agents Journal of University of Shanghai for Science and Technology. 2020; 22(11): 1854-1869.
  58. Suryawanshi V, Yadav A, Mohite S. Toxicological Assessment using Brine Shrimp Lethality Assay and Antimicrobial activity of Capparis Grandis. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 746-759.
  59. Pathade K, Mohite S, Yadav A. 3D-QSAR And ADMET Prediction Of Triazine Derivatives For Designing Potent Anticancer Agents. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 1816-1833.
  60. Rode P, Yadav A, Chitruk A, Mohite S, Magdum C. Microwave assisted synthesis, toxicological assessment using brine shrimp lethality assay and antimicrobial potential of new series of benzimidazole derivatives. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22900-22905.
  61. Bhosale M, Yadav A, Magdum C, Mohite S. Molecular Docking Studies, Synthesis, Toxicological Evaluation using Brine Shrimp (Artemia salina L.) Model and Anti-inflammatory Activity of Some N-(substituted)-5-phenyl-1,3,4-thiadiazol-2-amine Derivatives. Int J Sci Res Sci & Technol. 2020; 7(5): 51-62.
  62. Jagtap N, Yadav A, Mohite S. Synthesis, Molecular Docking Studies and Anticancer Activity of 1,3,4-Oxadiazole-3(2H)-thione Derivatives. Journal of University of Shanghai for Science and Technology.2020; 22(11):535-550.
  63. Bhosale M, Yadav A, Magdum C, Mohite S. Microwave Assisted Synthesis, Molecular Docking Studies and Anticancer Screening of Some 1,3,4-thiadiazole Derivatives. Journal of University of Shanghai for Science and Technology.2020; 22(11):520-534.
  64. Birajdar R, Yadav A, Patil S, Chitruk A, Kane S, Mohite S, Magdum C. Pharmacognostic and Phytochemical Investigation, Molecular Docking Studies of Phytoconstituents and Anticancer Potential of Capparis Decidua (Forsk) Edgew. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 500-519.
  65. Pathade K, Mohite S, Yadav A. Synthesis, Molecular Docking Studies of Novel 4-(Substituted Phenyl Amino)-6-(Substituted Aniline)-N’-Aryl-1,3,5-Triazine-2-Carbahydrazide Derivatives As Potent Antitubercular Agents. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 1891-1909.
  66. Bhosale M, Yadav A, Magdum C, Mohite S. Synthesis, molecular docking studies and biological evaluation of 1,3,4-thiadiazole derivatives as antimicrobial agents. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22894-22899.
  67. B. R. Panda, S. R. Mohanta, A. K. Manna, S. Si. Invitro antioxidant activity on the aerial parts of Cocculus hirsutus Diels. J Adv Pharm Res. 2011; 2(1): 18-23.
  68. Udayakumar R, Kasthurirengan S, Vasudevan A, Mariashibu TS, Rayan JJ, Choi CW, Ganapathi A, Kim SC. Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats. Plant Foods Hum Nutr. 2010; 65: 91-98.
  69. Kosanic M, Rankovic B, Stanojkovic T, Rancic A, Manojlovoic N. Cladonia lichens and their major metabolites as possible natural antioxidant, antimicrobial and anticancer agents. LWT Food Sci. Technol. 2014; 59: 518–525.
  70. Papadopoulou P, Tzakou O, Vagias C, Kefalas P, Roussis V. Beta-orcinol metabolites from the lichen Hypotrachyna revoluta. Molecules. 2007; 12: 997–1005.
  71. Jayaprakasha G.K, Rao L J. Phenolic constituents from the lichen Parmotrema stuppeum (Nyl.) Hale and their antioxidant activity. Z. Naturforsch. C. 2000; 55: 1018–1022.
  72. Vishwananthan B, Gurupadayya B, Sairam K, Inturi B. Design, synthesis, In vitro antioxidant and in vivo anti-inflammatory activities of novel oxadiazole derivatives. Int J Pharm Pharm Sci. 2014; 6(9): 514-520.
  73. Adesegun S, Fajana A, Orabueze C, Coker H. Evaluation of antioxidant properties of phaulopsis fascisepala C.B.Cl. (Acanthaceae). Evid Based Complement Alternat Med. 2009; 6: 227 231.

International Journal of Scientific Research in Chemistry

Downloads

Published

2020-12-30

Issue

Volume 5, Issue 6, November-December-2020

Section

Research Articles

License

Copyright (c) IJSRCH

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Nilesh J. Pawara, Akshay R. Yadav, Dr. Shrinivas K. Mohite, " Pharmacognostic, Phytochemical Investigation and Antioxidant Potential of Embelia ribes, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 5, Issue 6, pp.27-34, November-December-2020.