Role of Medicinal Chemistry in the Current Scenario
Keywords:
Medicinal chemistry, Drug molecules, Molecular hybridization, Molecular docking, QSAR study, ADMET assessment.Abstract
Medicinal chemistry is defined as an interdependent mature science, a combination applied medicine and basic chemistry that involves discovering, developing, identifying and interpreting the biologically active compounds. It plays major role in drug research and development by taking advantage of recent technique with advanced knowledge of different branches of related sciences. Since it can be seen as a melting pot of organic chemistry with molecular pharmacology further emphasizes the study of the relationship of drug molecules structural activity so it requires knowledge of chemical and pharmacology concepts. The source of medicinal chemistry lies in all branches of biology and chemistry, which started its journey in the war against various diseases in Ehrlich's hands, who dreamed of a "magic bullet" to combat various infectious diseases. ADMET assessment of therapeutic drug classes influence on therapeutic decision. Top-flight medicinal chemists can play greater roles in improving drug-creation efficiencies and clinical success rates, thereby increasing the overall cost-effectiveness of the enterprise and, in turn, more quickly satisfying unmet medical needs.
References
- Khan M, Deimling M, Philip A. Medicinal chemistry and the pharmacy curriculum. Am J Pharm Educ. 2011; 75(8): 1-10.
- Graham P. Medicinal chemistry. Oxford university publishers. 2005; 4: 185-254.
- Yadav A, Mohite S. Anticancer activity and In-silico ADMET analysis of malvastrum coromandelianum. Int J Pharma Sci Res. 2020; 11(5): 71-73.
- Hughes J, Rees S, Kalindjian S, Philpott K. Principles of early drug discovery. Br J Pharmacol. 2011; 162(4): 1239–1249.
- Yadav A, Mohite S. Cancer- A Silent Killer: An Overview. Asian J. Pharm. Res. 2020; 10(3): 213-216.
- Bala S, Khamboj S, Kajal A, Saini V, Prasad D. 1,3,4-oxadiazole Derivatives: Synthesis, characterization, antimicrobial potential, and computational studies. Biomed Res Int. 2014; 9(2): 1-18.
- Subbaiah N, Mohanty S, Sudha B, Ayyanna C. Synthesis, characterization and evaluation of antibacterial & anti-fungal activity of 2,5-disubstituted 1,3,4-oxadiazole derivatives. Int J Pharm Pharm Sci. 2016; 1(2): 39-42.
- Yadav A, Mohite S. Design, synthesis and characterization of some novel benzamide derivatives and it’s pharmacological screening, Int. j. sci. res. sci. technol. 2020; 7(2): 68-74.
- Dubey V. Design, facile synthesis, and antibacterial activity of hybrid 1,3,4-thiadiazole-1,3,5-triazine derivatives tethered via-S-bridge. chem. Bio des. 2012; 80(4): 598-604.
- Yadav A, Mohite S. Green chemistry approach for microwave assisted synthesis of some traditional reactions. Asian J. Research Chem. 2020; 13(4): 261-264.
- Yadav A, Mohite S. A Brief Review: Microwave chemistry and it’s applications. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 191-197.
- Yadav A, Mohite S, Magdum C. Microwave assisted synthesis of some traditional reactions: Green chemistry approach. Asian J. Research Chem. 2020; 13(4): 275-278.
- Surati M, Jauhari S, Desai K. A brief review: Microwave assisted organic reaction. Arch. Appl. Sci. Res. 2012; 4(1): 645-661.
- Chitruk A, Yadav A, Rode P, Mohite S, Magdum C. Synthesis and toxicological evaluation using brine shrimp lethality assay of Novel 1,2,4-triazole derivatives with anticancer activity. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22877-22881.
- Yadav A, Mohite S, Magdum C. Comparative Study of Conventional and Microwave Assisted Synthesis of some Organic Reactions. Asian J. Pharm. Res. 2020; 10(3): 217-220.
- Jagtap N, Yadav A, Mohite S. Synthesis, Molecular Docking Studies and Anticancer Activity of 1,3,4-Oxadiazole-3(2H)-thione Derivatives. Journal of University of Shanghai for Science and Technology. 2020; 22(11): 535-550.
- Yadav A, Mohite S. Different Techniques and Characterization of Polymorphism with their Evaluation: A Review. Asian J. Pharm. Tech. 2020; 10(3): 213-216.
- Rode P, Yadav A, Chitruk A, Mohite S, Magdum C. Microwave assisted synthesis, toxicological assessment using brine shrimp lethality assay and antimicrobial potential of new series of benzimidazole derivatives. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22900-22905.
- Nerkar A, Pawale D, Ghanate M, Sawant S. Microwave assisted organic synthesis of some traditional and named reactions: A practical approach of green chemistry. Int J Pharm Pharm Sci. 2013; 5(3): 564-566.
- Chitruk A, Yadav A, Rode P, Mohite S, Magdum C. Microwave assisted synthesis, antimicrobial and anti-inflammatory potential of some novel 1,2,4-triazole derivatives. Int. j. sci. res. sci. technol. 2020; 7(4): 360-367.
- Gaba M, Dhingra N. Microwave chemistry: General features and applications. Ind J Pharm Edu Res. 2011; 45(2): 175-183.
- Gupta M, Paul S, Gupta R. General characteristics and applications of microwave in organic synthesis. Acta Chim Slov. 2009; 56(2): 749-764.
- Gedye R, Smith F, Westaway K. The use of microwave ovens for rapid organic synthesis. Tetrahedron Lett. 1986; 27(9): 279-282.
- Chitruk A, Yadav A, Rode P, Mohite S, Magdum C. Synthesis and toxicological evaluation using brine shrimp lethality assay of novel 1,2,4-triazole derivatives with anticancer activity. Int. J. Curr. Adv. Res. 2020; 9(8)(A): 22877-22881.
- Gasgnier M, Loupy A, Petit A, Jullien H. New developments in the field of energy transfer by means of monomade microwaves for various oxides and hydroxides. J. Alloys Comp. 1994; 204(2): 165-172.
- Rode P, Yadav A, Chitruk A, Mohite S, Magdum C. Microwave assisted synthesis, toxicological assessment using brine shrimp lethality assay and antimicrobial potential of new series of benzimidazole derivatives. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22900-22905.
- Rajak H, Mishra P. Microwave assisted combinatorial chemistry: The potential approach for acceleration of drug discovery. J Sci Indus Res. 2004; 63(5): 641-654.
- Yadav A, Mohite S, Magdum C. Comparative study of conventional and microwave assisted synthesis of some organic reactions. Asian J. Pharm. Res. 2020; 10(3): 217-220.
- Ravichandran S, Karthikeyan E. Microwave synthesis a potential tool for green chemistry. Int J Chem Tech Res. 2011; 3(1): 466-470.
- Honmane P, Yadav A, Singh S, Mohite S. Synthesis of Pyrazole Acrylic acid based Oxadiazole and Amide Derivatives as Larvicidal and Antitubercular agents. Seybold Rep. 2020; 25(10): 516-530.
- Bhosale M, Yadav A, Mohite S, Magdum C. Synthesis, molecular docking studies and biological evaluation of 1,3,4-thiadiazole derivatives as antimicrobial agents. Int. J. Curr. Adv. Res. 2020; 09(08)(A): 22894-22899.
- Indalkar K. Novel 2-phenyl-4,5,6,7-tetrahydrob]-benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation and molecular docking studies. Bioorg Med Chem Lett. 2017; 27(8): 1721-1726.
- Rode P, Yadav A, Chitruk A, Mohite S, Magdum C. Synthesis, anticancer and molecular docking studies of N-(1H-benzimidazol-2-yl-carbamothioyl)benzamide analogues. Int. j. sci. res. sci. technol. 2020; 7(4): 204-212.
- Muhammad U, Uzairu A, Arthur D. Review on: Quantitative structure-activity relationship (QSAR) modelling. J Anal pharm res. 2018; 7(2): 240-242.
- Pollaro L, Heinis C. Strategies to prolong the plasma residence time of peptide drugs. Med. Chem. Comm. 2010;1:319–324.
- McGregor DP. Discovering and improving novel peptide therapeutics. Curr. Opin. Pharmacol. 2008;8(5):616–619.
- Hess S, Ovadia O, Shalev DE, et al. Effect of structural and conformation modifications, including backbone cyclization of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability. J. Med. Chem. 2007;50:6201–6211.
- Swinney DC, Anthony J. How were new medicines discovered? Nat. Rev. Drug Discov. 2011;10(7):507–519.
- Gleeson MP, Hersey A, Montanari D, Overington J. Probing the links between in vitro potency, ADMET and physicochemical parameters. Nat. Rev. Drug Discov. 2011;10(3):197–208.
- An audience with Susan Desmond-Hellmann. News and analysis. Nat. Rev. Drug Discov. 2011;10(3):170.
- Translational medicine. Career snapshots. Nat. Rev. Drug Discov. 2009;8(7):593.
- Ratner M. Pfizer reaches out to academia–again. Nat. Biotechnol. 2011;29(1):3–4.
- Tralau-Stewart CJ, Wyatt CA, Kleyn DE, Ayad A. Drug discovery: new models for industry-academic partnerships. Drug Discov. Today. 2009;14(1/2):95–101.
Downloads
Published
Issue
Section
License
Copyright (c) IJSRCH

This work is licensed under a Creative Commons Attribution 4.0 International License.