Computational Evaluation by In-silico Pharmacokinetics and Drug-likeness Prediction of 1,4-naphthoquinones Derivatives with [1,2,4]-triazole-3-thione Substitution as Potent Insecticidal agents

Authors

  • Akshay R.Yadav   Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli, Maharashtra, India

Keywords:

ADME studies, 1,4-naphthoquinones, [1,2,4]-triazole-3-thione, Pharmacokinetic properties, Drug-likeness, Insecticidal agents.

Abstract

Naphthoquinones are wide-spread phenolic compounds in nature. They are products of bacterial and fungal as well as high-plants secondary metabolism. Juglone, lawsone, and plumbagin are the most widespread compounds. Naphthoquinones display very significant pharmacological properties--they are cytotoxic, they have significant antibacterial, antifungal, antiviral, insecticidal, anti-inflammatory, and antipyretic properties. ADMET studies have also been performed using the SwissADME web tool to verify the pharmacological similarity of designed compounds. Hence, the present investigation studies will provide a new vision for the discovery of potent insecticidal agents.

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International Journal of Scientific Research in Chemistry

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2021-02-28

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Volume 6, Issue 1, January-February-2021

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[1]
Akshay R.Yadav , " Computational Evaluation by In-silico Pharmacokinetics and Drug-likeness Prediction of 1,4-naphthoquinones Derivatives with [1,2,4]-triazole-3-thione Substitution as Potent Insecticidal agents, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 6, Issue 1, pp.44-52, January-February-2021.