Synthesis, Characterization and Antimicrobial Studies of Co(II) and Ni(II) Schiff Base Complexes Derived Furfuraldehyde and Sulfamethoxazole

Authors

  • Siraj I. T.  Department of Pure and Industrial Chemistry, Bayero University Kano, Kano State, Nigeria
  • Sanusi S.  Department of Pure and Industrial Chemistry, Bayero University Kano, Kano State, Nigeria

Keywords:

Schiff base, sulfamethoxazole, furfuraldehyde, spectroscopic study, antimicrobial activity

Abstract

Complexes of Co(II)and Ni(II) with Schiff base derived from sulfamethoxazole and furfural have been synthesized and characterized via physical characteristics, analytical data, FT-IR spectral studies and elemental analysis. Infrared spectral data of the Schiff base and that of the complexes concurs with the formation and chelation of the Schiff base through the azomethine nitrogen at 1629 cm-1 and aldehydic oxygen at 1288 cm-1. Molar conductance measurement of 17.32 and 3.52 Ohm-1 cm2 mol-1 suggested a non- electrolytic nature of the all complexes. Magnetic susceptibility data (4.33 and 3.00 BM) suggested octahedral structure for all the synthesized complexes. Elemental analysis suggested the ligand-metal ratio of 2:1 respectively. The Schiff base melted at 180°C and the complexes decomposed at 239°C and 241°C, this implies a good thermal stability. The Schiff base and the complexes have been screened for their antimicrobial activity against four pathogenic microbes; Staphylococcus aureus, Escherichia coli, Aspergillus flavus and Candida albicans. The ligand showed moderate activity with inhibition zone in the range of 8 – 14mm, while the metal complexes exhibited higher antimicrobial activity with inhibition zone of 8 – 15mm against the tested microbes.

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International Journal of Scientific Research in Chemistry

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Published

2021-08-28

Issue

Volume 6, Issue 4, July-August-2021

Section

Research Articles

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How to Cite

[1]
Siraj I. T., Sanusi S., " Synthesis, Characterization and Antimicrobial Studies of Co(II) and Ni(II) Schiff Base Complexes Derived Furfuraldehyde and Sulfamethoxazole, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 6, Issue 4, pp.01-09, July-August-2021.