Spectrophotometric Determination of L-Ascorbic Acid Based on its Oxidation by Potassium Peroxymonosulfate in an Acidic Medium

Authors

  • Halid Junuzovic  Department of Analytical chemistry, University of Tuzla/Faculty of Technology, Tuzla, Bosnia and Herzegovina
  • Mirsad Salkic  Department of Analytical chemistry, University of Tuzla/Faculty of Technology, Tuzla, Bosnia and Herzegovina
  • Amra Selimovic  Department of Analytical chemistry, University of Tuzla/Faculty of Technology, Tuzla, Bosnia and Herzegovina
  • Mersiha Suljaknovic  Department of Analytical chemistry, University of Tuzla/Faculty of Natural Sciences and Mathematics, Tuzla, Bosnia and Herzegovina

Keywords:

ascorbic acid, oxidation, peroxymonosulfate, spectrophotometry, pharmaceutical preparations

Abstract

A selective and accurate direct spectrophotometric method was developed for the determination of L-ascorbic acid in pharmaceutical preparations. Background correction was based on the oxidation of L-ascorbic acid by potassium peroxymonosulfate in an acidic medium (pH 4.00). The molar absorptivity of the proposed method was 8.77 ?103 L mol?1 cm?1 at 246 nm. Beer's law was obeyed in the concentration range of 2.37 – 20.00 ?g/mL for L-ascorbic acid. The detection limit was 0.71 ?g/mL, and the relative standard deviation was 0.97% (n = 7) for 12.00 ?g/mL L-ascorbic acid. Other compounds commonly found in pharmaceutical preparations did not interfere with the detectiON of L-ascorbic acid. The proposed method was successfully applied to the determination of L-ascorbic acid in pharmaceuticals, and the results obtained agreed with those obtained by iodine titration.

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International Journal of Scientific Research in Chemistry

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Published

2021-12-30

Issue

Volume 6, Issue 6, November-December-2021

Section

Research Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Halid Junuzovic, Mirsad Salkic, Amra Selimovic, Mersiha Suljaknovic, " Spectrophotometric Determination of L-Ascorbic Acid Based on its Oxidation by Potassium Peroxymonosulfate in an Acidic Medium, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 6, Issue 6, pp.01-06, November-December-2021.