Beneficial and toxicological response of Oxytocin with stability, detection, marketing and authorization: a receptor mediate Approach

Authors

  • Sandeep Mishra  Department of Chemistry, SGS Govt. PG College, Sidhi, Madhya Pradesh, India
  • P.K. Singh  Department of Chemistry, SGS Govt. PG College, Sidhi, Madhya Pradesh, India
  • Rajesh Pandey  Department of Biochemistry, APS University, Rewa, Madhya Pradesh, India
  • Sandeep K. Soni  Department of Biochemistry, APS University, Rewa, Madhya Pradesh, India
  • Babbulal Patel  Department of Chemistry, SGS Govt. PG College, Sidhi, Madhya Pradesh, India
  • Rajesh K. Patel  Department of Chemistry, SGS Govt. PG College, Sidhi, Madhya Pradesh, India

Keywords:

Oxytocin, stability, detection, marketing and authorization, toxicology

Abstract

Peptide hormone Oxytocin has the distinction of being the first among the peptide hormones to be sequenced and biochemically produced. Oxytocin is involved in a wide spectrum of activities from milk letdown, parturition, ejaculation and erection to social, sexual and maternal performance. Since of the spectrum of its meanings it has been used therapeutically for conditions by performing the Oxytocin receptors (OR) mediate activity, oxytocin are connected by means of Gq proteins which enrolled to GTP revive the action of Phospholipase-C enzyme. Due to gives rise and activation one by one biochemical consequences occur that activate the Phospholipase-C enzyme at the end. The Phospholipase-C enzyme responsible by means of produce 1, 2-diacyl glycerol along with Inositol triphosphate, Inositol triphosphate grounds release intracellular basis Ca2+ ions, which in turn origins a direction of cellular process. Oxytocin being credible agent to excited the plant growth in variable aspects. The redeployment of macrobiotic and micro biotic nutrients among tissues and seeds of plants proved beneficial results in terms of plants anatomy and physiology with certain toxicological and beneficial response by means of stability, detection, marketing and authorization in diverse way.

References

  1. Vigneaud VD, Ressler C, Swan CJM, Roberts CW, Katsoyannis PG, Gordon S. The synthesis of an octapeptide amide with the hormonal activity of oxytocin. J. American Chem. Society. 1953; 75(19): 4879-4880.
  2. Kabilan A. Pharmacological role of oxytocin a short review. J. of Pharmaceutical Sci and Research. 2014; 6(4): 220-232.
  3. Sheldric EL. Flint AP. Post-translational processing of Oxytocin neuro physinprohormone in the ovine corpus luteum: activity of peptidylglycine alpha amidating mono oxygenase and concentrations of its cofactor, ascorbic acid. J. of Endocrinol.1989; 122(1): 313-322.
  4. Chandravati C, Mahadevan K, Sheela PK, Kumari S, Hashiv R, Ahmed M. Detection of oxytocin in fruits and vegetables using wireless sensor. Indian J. of Sci and Tech. 2016; 9 (16):
  5. Kumar P, Sharma P, Vats Binny, Kumar A, Kumar P. Effect of Oxytocin application on growth and yield of parthenocarpic cucumber under protected environments. Inter J. of Current Adv Research.2017; 6(12): 8106-8108.
  6. Bartz JA, Hollander E. Oxytocin and experimental therapeutics in autism spectrum disorders. Proceeding in brain Research. 2008; 170: 451-462.
  7. Guastella AJ, Einfeld E, Gray K, Rinehart N, Tonge B, Lambert TJ, Hickie IB. Intranasal Oxytocin improves emotion recognition of youth with autism spectrum disorders. Bio psychiatry. 2010; 67(7): 692-694.
  8. Andaria E, Duhamela JR, Zallab T, Herbrechtb E, Leboyerb M, Sirigu A. Promoting social behaviour with Oxytocin in high functioning autism spectrum disorders. Proc Nat Acad Sci USA. 2010; 107(9): 4389-4894.
  9. Kohli D, Adulterated food becoming more common in India. Asia Pacific News (Internet) Available http://www.channelnewsasia.com/stories/southasia/view/1076488/1/.html.2015
  10. Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H. Structure and expression of a human Oxytocin receptor. Nature. 1992; 356:526-529.
  11. Gimpl G, Fahrenholz F. The Oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001; 81:629-683.
  12. ICH Q1A (R2). Stability testing of new drug substances and products (current version). 2003.
  13. Chaibva FA, Walker RB. Development and validation of a stability-indicating analytical method for the quantification of oxytocin in pharmaceutical dosage forms. J. Pharm Biomed Anal. 2007;43:179-185.
  14. Hawe A, Poole R, Romeijn S, Kasper P, Vander HR, Jiskoot W. Towards heat-stable oxytocin formulations: analysis of degradation kinetics and identification of degradation products. Pharmaceutical Research. 2009; 26(7):1679-1688.
  15. Nachtmann F, Krummen K, Maxl F, Reimer E. Oxytocin: Analytical profiles of drug substances. Anal Pro Drug Subst. 1981;10:563-600.
  16. Hogerzeil HV, Walker GJA, Degoeje MJ. Stability of injectable oxytocins in tropical climates. WHO report WHO/DAP/93.6. 1993.
  17. Heeb A, Lundegårdh B, Savage G, Ericsson T. Impact of organic and inorganic fertilizers on yield, taste, and nutritional quality of tomatoes. J. of plant nutrition and soil sci, 2006; 169(4): 535-541.
  18. Prakash BS, Paul V, Kliem H, Kulozik U, Meyer HHD. Determination of oxytocin in milk of cows administered oxytocin. Analytica Chimica Acta. 2009; 636(1):111-115.
  19. PTI. Eating oxytocin-laced vegetables harmful in long term:Experts. Deccan Herald Internet2015
  20. Mustafa MY, Saleem K , Munir R, Butt TM. Effect of Oxytocin Administration before Milking on Milk Production, Somatic Cells Count and fat Contents in Milk of Nili-Ravi Buffaloes Pakistan veterinary J. 2008. 32(3): 435-437.
  21. Gaspar T, Kevers, C, Penel C, Greppin H, Reid DM, Thorpe TA. Plant hormones and plant growth regulators in plant tissue culture. In vitro Cellular and Dev Bio-Plant. 1996; 32(4): 272-289.
  22. Rani R, Medhe S, Raj KR, Srivastava M. Standardization of HPTLC method for the estimation of oxytocin in edibles. J of food Sci and Tech. 2013; 50(6):1222-1227.
  23. Tori DA. Drip Understanding Oxytocin and Bonding Understanding Oxytocin and Bonding. 2008;39(2):30-39.
  24. Ahmad KM, Nazir A, Mansoor MK. Abuses of Oxytocin in cows and buffaloes. Pakistan veterinary j. 2000; 20(3):161-162.
  25. Marnia R. Oxytocin, Fidelity and Sex. Cupid's Poisoned Arrow. 2012
  26. Navneet M, Sanjay K. The orgasmic history of Oxytocin:Love, lust, and labor. Indian J Endocrinol Metab. 2011; 15(3):156-161.
  27. Kendrick KM. The neurobiology of social bonds. J Neuroendocrinol. 2004; (16): 1007-1088.
  28. Natzke RP. Schultz LH. Effect of Oxytocin injections on mastitis screening tests and milk composition. Journal of Dairy sciences. 1996; 50(1): 43-46.
  29. Parashar RP. President of DAV society for health, report of survey conducted for misuse of Oxytocin in UP, Haryana and Delhi. 1997.
  30. Gimpl G. and Fahrenholz F. The Oxytocin receptor system: structure, function, and regulation. Physiol Rev. 2001; 81: 629-683.

International Journal of Scientific Research in Chemistry

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Published

2022-02-28

Issue

Volume 7, Issue 1, January-February-2022

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Research Articles

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How to Cite

[1]
Sandeep Mishra, P.K. Singh, Rajesh Pandey, Sandeep K. Soni, Babbulal Patel, Rajesh K. Patel, " Beneficial and toxicological response of Oxytocin with stability, detection, marketing and authorization: a receptor mediate Approach, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 7, Issue 1, pp.23-32, January-February-2022.