Synthesis and Characterization of Three New Schiff Base Complexes of Metals (II) Derived from a Mix of Drugs Sulfamethaxole with 2-aminopyridine and Benzaldehyde
Keywords:
Synthesis, Schiff base, Complexes, Sulfamethaxole, Benzaldehyde.Abstract
In this research, 2-Aminopyridine and Benzaldehyde was synthesized to give a Schiff base (L1). The Transition Metal Complexes were prepared by the reaction of the Schiff Base and Metal (II) Salt in a 2:1 molar ratio {M: 2(L1)}. While the mixed ligand Complexes were synthesized by reaction of Schiff base with Metals (II) salt and Sulfamethoxazole Drug in a ratio of 1:1:1 {M: (L1): (L2)}. Modern and purity of these complexes were determined using melting point, texture, color, solubility and molar conductivity. The Schiff Base, the Metal (II) complexes and the mixed ligand Complexes were characterized using FT-IR and VU-Visible spectroscopic. It was found that in the Metal (II) Complexes bound to the Metal through Nitrogen (N) and azomethine. While in the mixed ligand Complexes both the Schiff base and Sulfamethaxazole drug are bound to the Metal through Nitrogen (N) and Oxygen (O) or azomethine.
References
- Warra A.A, Transition metal complexes and their application in drugs and cosmetics – A Review Journal of Chemical and Pharmaceutical Research. 3, 951 (2011).
- Rafique S., Idrees M., Nasim A., Akbar H., & Athar, A., Transition metal complexes as potential therapeutic agents. Biotechnology and Molecular Biology Reviews, 5: 38 (2010).
- Mumtaz A, Mahmud T, Elsegood MR, Weaver GW., Synthesis and Characterization of New Schiff Base Transition Metal Complexes Derived from Drug Together with Biological Potential Study. J Nucl Med Radiat Ther. 7: 310 (2016).
- Ndahi N.P and Nasiru Y.P., Complexes of Cobalt (II) and Zinc (II) with Schiff Base Derived from 4-Anisaldehyde. International Journal of Pharmaceutical Science and Research. 3: 0975 (2012)
- Mahmud T., Synthesis and characterization of the amino acid Schiff bases and their complexes with copper (II). In School of Chemistry University of Manchester: Manchester. p. 4 (2010).
- Raman N, Kulandaisamy A, Shanmugasundaram A, Jeyasubramanian K., Synthesis spectral, redox and antimicrobial activity of Schiff base complexes derivedfrom1-phenyl-2-3-dimethyl-4-aminopyrazol-5-oneand acetoacetanilide. Journal of transition Metal Chemistry 26:131 (2001).
- Abdullahi O. Sobola, Gareth M. Watkins, Synthesis, Characterization and Biological study of Cu(II) complexes of aminopyridine and (aminomethyl) pyridine. Journal Serbia of Chemical Soc. 83: 809 (2018).
- Mohamed G.G, Zayed M.A, Abdallah S.M, Metal complexes of a novel Schiff base derived from sulphametrole and varelaldehyde, Synthesis, spectral, thermal characterization and biological activity. Journal of Molecular Structure: 71 (2010).
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