Green Approach in the Synthesis of Substituted Imidazole

Authors

  • Ajay M. Patil  Department of Chemistry, Pratishthan College Paithan, Aurangabad, India.
  • Kailash R.Borude  Department of Chemistry,Katruwar arts Kabra Science College Manwath,Parbhani ,India.
  • Archana Kachare  Department of Chemistry, Sunderrao Solanke Mahavidyalaya Majalgaon, Dist.-Beed India.
  • Mahananda Raut  Department of Chemistry, Pratishthan College Paithan, Aurangabad, India.

Keywords:

Imidazole, Chitosan, Green Catalyst, Polysaccharide

Abstract

A convenient and rapid method is described for the synthesis of nitrogen heterocyclic derivatives by one-pot three component reaction of substituted aromatic aldehydes, Benzil and Ammonium Acetate using commercially available chitosan in 2% acetic acid in aqueous media at 60?65°C. Chitosan, as a biocompatible and biodegradable pseudo-natural polysaccharide is one of the excellent choices for the preparation of suitable catalytic systems due to its unique properties. Chitosan was used as an efficient biodegradable and reusable green catalyst for this multicomponent reaction. The chitosan catalyst can be reused 10 times in fresh reaction. Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazoleAmong the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs.

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International Journal of Scientific Research in Chemistry

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Published

2022-12-30

Issue

Volume 7, Issue 6, November-December-2022

Section

Research Articles

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How to Cite

[1]
Ajay M. Patil,Kailash R.Borude, Archana Kachare, Mahananda Raut, " Green Approach in the Synthesis of Substituted Imidazole, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 7, Issue 6, pp.07-12, November-December-2022.