Synthesis of Symmetrical and Unsymmetrical Thiourea Derivatives and their Biological Activities

Authors

  • Sunbal  Institute of Chemical Sciences, University of Swat, Mingora, Swat, Khyber Pakhtunkhwa, Pakistan
  • Ihsanullah  Institute of Chemical Sciences, University of Swat, Mingora, Swat, Khyber Pakhtunkhwa, Pakistan

Keywords:

Synthesis, Thiourea Ligands, Complexes, Antibacterial And Antileishmanial Activity

Abstract

In this study different derivatives of thiourea have been prepared; both symmetrical and unsymmetrical. For the synthesis of symmetrical thiourea derivatives, substituted anilines were combined with carbon disulphide (CS2) in water, whereas for the synthesis of unsymmetrical thiourea derivatives, potassium thiocyanate (KSCN) was first combined with acid chlorides derivatives in dry acetone before primary amines were gradually added to this solution. Thin layer chromatography (TLC) was used to check each response. The reaction mixtures were filtered and rinsed with ethanol after the completion of the reaction. The synthesized products were characterized by different spectroscopic techniques. For their ability to fight germs and leishmania, all of these substances were examined. These substances demonstrated excellent activity while some of them showed only moderate activity.

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International Journal of Scientific Research in Chemistry

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Published

2023-06-30

Issue

Volume 8, Issue 3, May-June-2023

Section

Research Articles

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How to Cite

[1]
Sunbal, Ihsanullah, " Synthesis of Symmetrical and Unsymmetrical Thiourea Derivatives and their Biological Activities , International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 8, Issue 3, pp.22-28, May-June-2023.