Pharmacopeial Standard Development, HPTLC Fingerprinting and Physicochemical, Research Studies of Polyherbal Classical Drug Raughan-E-Mukhtara

Authors

  • Pawan Kumar Sagar  Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PCIM&H Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India
  • N. Z. Ahmed  Central Council for Research in Unani Medicine,(Under Ministry of AYUSH., Govt. of India),61-62, Institutional Area, Janakpuri, New Delhi, India
  • A. S. Khan  Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PCIM&H Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India
  • R. P. Meena  Central Council for Research in Unani Medicine,(Under Ministry of AYUSH., Govt. of India),61-62, Institutional Area, Janakpuri, New Delhi, India
  • M. W. Ahmed  Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PCIM&H Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India
  • S. A. Ansari  Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PCIM&H Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India
  • S. Sajwan  Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PCIM&H Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India
  • S. Kashyap  Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India), PCIM&H Campus, IInd Floor, Kamla Nehru Nagar, Ghaziabad, U.P., India

Keywords:

Raughan-e-Mukhtara (REM), Arthritis, Analgesic, Anti-Inflammatory, development of pharmacopeial standards, physicochemical, comparative screening, quality control and assurance.

Abstract

Raughan-e-Mukhtara a classical Unani formulated medicated oil used in the treatment of Arthritis, Anti-Inflammatory, Analgesic, relief in Nervine Pain, and other Neurological disorders from since ancient time. In these studies which 3 Batches of formulated drug were prepared B1,B2 and B3, applied and developed SOP on the basis of authenticated classic text & Literature, standard methods. The quality control & quality assurance studies were conducted in accordance to the WHO., AOAC., IPC. and UPC., approved guidelines. The physicochemical data showed Extractive, %, w/v. (100), that the drug samples contained Petroleum ether(60-80°C), Acid value (10.83), Iodine value (26.02), Peroxide value(12.93), Saponification Value (218.56), Unsaponifiable matter,% (2.01),Refractive index (1.4653),Weight per ml.(gm.) (0.8848),Test for presence of Arachis oil, Cotton seed oil and Mineral oil both are found negatives were assessed in REM. HPTLC. studies of alcohol extracts of different Batches B1.B2 and B3 of REM. Showed in various spots at 366nm (UV. region),under exposed to Vinyl - Sulfuric acid reagent. derivatized obtained with equate, best separation using selected suitable solvent system of mobile phase. The quality control studies results revealed the absence of hazardous and toxic contamination from the drug sample. Moreover the obtained research studies data and comparative physicochemical, phytochemical and HPTLC Fingerprinting identification screening will provide the referential supportive information in the development of pharmacopeial standard monographs, identification of classical formulation, reinvestigation, quality assurance and pharmacovigilance and validation of the Quality standard of REM classical drug, providing the quality medicine to needful public mass of the World.

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International Journal of Scientific Research in Chemistry

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Published

2023-08-30

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Volume 8, Issue 4, July-August-2023

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Research Articles

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[1]
Pawan Kumar Sagar, N. Z. Ahmed, A. S. Khan, R. P. Meena, M. W. Ahmed, S. A. Ansari, S. Sajwan, S. Kashyap, " Pharmacopeial Standard Development, HPTLC Fingerprinting and Physicochemical, Research Studies of Polyherbal Classical Drug Raughan-E-Mukhtara , International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 8, Issue 4, pp.38-52, July-August-2023.