Synthesis, Spectral analysis and Biological Studies on Newly Derivatives of Amino salicylic acid
Keywords:
Synthesis, Spectral analysis, Biological and 5 -ASA.Abstract
In the present investigation Syntheses and Biological studies on some new derivatives of 5 – Amino Salicylic acid. Methyl, 5 – Amino Salicylic acid and Ethyl 5 – Amino Salicylic acid derivatives were synthesized by 5 – Amino Salicylic acid and methanol and ethanol under- reflux method. The resulting crude precipitates were recrystallized from the absolute ethanol. The compounds were Characterized using Elemental Analysis, Infrared spectra, Proton and 13C NMR spectroscopic. UV - spectroscopic. This compound has been screened for their antimicrobial activities and fungi.
References
- Kruis W., Schreiber I., Theuer, Sehutz., Howaldt., Krakamp., Hamling et al., http://en.wikipedia.org/wiki/mesalazine.
- Sandborn W J., Feagan B G., Liehtenstein G R., htpp://www.interscience.wiley.com/legibin/fulltex. 2009-12-20
- Kombluth A, Sachar D.B., www.medscape.com/viewarticle/711314
- Travis SPL, Strange FF., Journal of Chron’s and Colitis: (2008) www.medscape.com/viewarticle/711314
- Qureshi A.T., Cohen R.D., Mesalamine delivery system, Adv Drug Deliv. Rev, 57, 281,302, (2005) www.medscape.com/viewarticle/711314
- Myers B, Evans D.N., Rhades J., et al. www.medscape.com/viewarticle/711314
- Cohea R.D., Aliment pharmacology Therapy (2006), 24:4657, (2010).
- Merck Index 14 th Edition Page - 80
- Vogel A.I.,“ Textbook of Practical Organic Chemistry” The ELBS & Longmans Green and Co., Ltd. London, Page 840-842, 4th Edition (1979).
- Knolker H .J; Bauermeister M; J. Indian Chem. Soc. 71, 345 (1994).
- Cruichshank R., Duguid J.P., Marmoin B.P., Swan H.A., The Practice of Medical Microbiology, Vol, 12th edn, Churchill Livingstone, London, page – 190, (1975).
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