Synthesis, Antimicrobial Activity and Characterization of Some Novel Thiozolo Pyrimidine Derivatives

Authors

  • J. S. Makwana  Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India
  • B. B. Baldaniya  Chemistry Department, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India

Keywords:

Thiozolo Pyrimidine, Antibacterial Activity, Antifungal Activities, Biginelli Reaction

Abstract

Thirteen new thiozolo pyrimidine derivatives have been synthesized from Biginelli reaction. The structures of derivatives were established on the basis of their elemental analysis, IR, NMR and Mass Spectral data. The title compounds have been tested for antibacterial and antifungal activities against different strains of bacteria.

References

  1. V. Tomar, G. Bhattacharjee, Kamaluddina, A. Kumar, Synthesis and antimicrobial evolution of new Chalcones containing piperazine or 2,5-dichlorothiophene moiety. Bioorg Med Chem Lett. 2007; 17, 5321-4.
  2. Y. R. Prasad, P. R. Kumar, J. Smiles, P. A. Babu, QSAR studies on chalcone derivatives as antibacterial agents against Bacillus Pumilis, Arkivic. 2008; 11, 266-76.
  3. J. N. Dominguez, C. Leon, J. Rodrigues, N. G. Dominguez, J. Gut, P. J. Rosenthal, synthesis and antimalarial activity of sulfonamide chalcone derivatives, Farmaco. 2005; 60, 307-11.
  4. B. B. Baldaniya, M. M. Jotani, (2Z)-Ethyl2-(3-methoxy-4-acetyloxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro- 5H-1, 3 thiazolo-[3, 2-a]pyrimidine-6-carboxylate. Indian J. Phys, 2010, 84 (9) 1177-1182.
  5. R. Kalirajan, S. U. Sivakumar, S. Jubie, B. Gowramma, B. Suresh, synthesis and biological evaluation of some heterocyclic derivatives of Chalcones., int J Chem Res., 2009, 1, 27-34.
  6. B. B. Baldaniya, N.C. Desai., M.T.Chhabaria., Amit Dodia and Ajit M. Bhavsar, Synthesis characterization, anticancer activity and QSAR- studies of some new tetrahydropyrimidines, European journal medicinal chemistry, Med.Che.Res, (2011) 20:1331–1339, medicinal chemistry research, DOI: 10.1007/s00044-010-9481-4.
  7. V. R. Gadhachanda, B. Wu, Z. Wang, K. L. Kuhen, J. Caldwell, H. Zondler, et al., 4-amino-pyrimidines as novel HIV-1 inhibitors., Bioorg Med Chem Lett., 2007, 17, 260-5.
  8. A. Agarwal, K. Srivastava, S. K. Puri, PMS Chauhana, antimalarial activity and synthesis of new trisubstituted pyrimidines., Bioorg Med Chem Lett., 2005; 15, 3130-2.
  9. M. T. Chhabria, H. G. Bhatt, H. G. Raval, P. M. Oza, synthesis and biological evaluation of some 5-ethoxycarbonyl-6-isopropylamino-4-(substitutedphenyl)aminopyrimidines as potent analgesic and anti-inflammatory agents., Bioorg Med Chem Lett., 2007, 17, 1022-4.
  10. B. B. Baldaniya, M. M. Jotani., Ethyl (2Z) 2-(2-chlorobenzylidene)-7 methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thiazolo [3,2-a] pyrimidine-6-carboxylate. Acta Cryst., 2007, E-63, o1937- o1939, ISSN 1600-5368.
  11. N. V. Desai, A. M. Bhavsar, B. B. Baldaniya, synthesis and antimicrobial activity of 5-imidazolinone derivatives, Indian J Pharm Sci. 2009, 71, 90-4.
  12. A. Solankee, S. Solankee, G. Patel., potential antibacterial agents; 5-imidazolones derivatives., Rasayan J Chem., 2008, 1, 228-31.
  13. T El-Sayed Ali, S Abdel-Aghfaar Abdel-Aziz, H Metwali El-Shaaer, F Ismail Hanafy, A Zaky El-Fauomy., synthesis of some new 4-oxo-4H-chromene derivatives Bearing Nitrogen Heterocyclic synthesis as antifungal agents., Turk J Chem., 2008, 32, 365-74.

International Journal of Scientific Research in Chemistry

Downloads

Published

2018-05-30

Issue

Volume 3, Issue 1, January-February-2018

Section

Research Articles

License

Copyright (c) IJSRCH

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
J. S. Makwana, B. B. Baldaniya, " Synthesis, Antimicrobial Activity and Characterization of Some Novel Thiozolo Pyrimidine Derivatives, International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 3, Issue 1, pp.23-33, January-February-2018.