Synthesis and Characterizations of Some New 1,3,5-triazine-2,4,6-Triamine based Derivatives as Potent Antimicrobial and Antiinfective Agents
Keywords:
1, 3, 5-triazine-2, 4, 6-triamines; Antibacterial activity; Antifungal activityAbstract
1,2,4-Triazines are the six membered heterocyclic compounds containing three nitrogen in its structure with general formula C3H3N3 .Some novel 1,3,5-triazine-2,4,6-triamine have been synthesized and characterized by elemental analyses. Introduction of -OCH3, -F, -NO2, -Cl and –Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities. The products have been tested for their antibacterial activity against gram (+)ve(POSITIVE) and gram (-)ve(NEGATIVE) bacteria and also on different strains of fungi.
References
- K. S. Atwal, B. N. Swanson, S. E. Unger, D. M. Floyd, S. Moreland, A. Hedberg, B. C. O'Reilly, J. E. T. Corrie, J. Med. Chem., 34, (1991), 806-811.
- O. Kappe, Tetrahedron, 49, (1993), 6937-7963.
- P. Biginelli, Ber, 24, (1891), 1317 & 2962.
- P. Biginelli, Ber, 26, (1893), 447.
- P. Biginelli, Gazz. Chim. Ital., 23, (1893), 360-416.
- B. C. O'Reilly, K. S. Atwal, Heterocycles 1987, 26, 1185-1188. K. S. Atwal, C. O'Reilly, J. Z. Gougoutas, M. F. Malley, Heterocycles 1987, 26, 1189-1192. K. S. Atwal, G. C. Rovnyak, B. C. O'Reilly, J. Schwartz, J.Org.Chem., 54, (1989), 5898-5907.
- D. Shutalev, V. A. Kuksa, Chemistry of Heterocyclic compounds, 31, (1995), 86-91. Engl. transl. from Khim. Geterotsicl. Soedin. (1995), 97-102.
- D. Shutalev, V. Kuksa, Khim. Geterotsicl. Soedin. (1997), 105-109.
- M. M. Jotani, B. B. Baldaniya, Ethyl 2-[(Z)2-[3-chlorobenzylidene]-7 methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thiazolo [3,2-a] pyrimidine-6-carboxylate., Acta Cryst., E-64, (2008), 739.
- M. M. Jotani, B. B. Baldaniya, Ethyl (2Z) 2-(2-chlorobenzylidene)-7 methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thiazolo [3,2-a] pyrimidine-6-carboxylate. Acta Cryst., .E-63, (2007),1937- 1939.
- B. B. Baldaniya, M. M. Jotani, (2Z)-Ethyl 2-(4-chlorobenzylidene)-7 methyl-3-oxo-5-phenyl-2,3-dihydro-5h-1,3 thiazolo [3,2-a] pyrimidine-6-carboxylate.Acta Cryst., E-62, (2006), 5871- 5873.
- B. Baldaniya, M. M. Jotani, J. P. Jasinski, (2Z)-Ethyl 2-(4-methoxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro- 5H-1, 3 thiazolo-[3, 2-a]pyrimidine-6-carboxylate. Acta Cryst., E66(3), (2009), 599-600.
- B. Baldaniya, M. M. Jotani, (2Z)-Ethyl2-(3-methoxy-4-acetyloxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro- 5H-1, 3 thiazolo-[3, 2-a]pyrimidine-6-carboxylate. Indian J. Phys., 84(9), (2010), 1177-1182.
- B. B. Baldaniya M. M. Jotani, E. R. T. Tiekink, (2Z)-Ethyl 2-(2-acetoxybenzylidene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro- 5H-1, 3 thiazolo-[3, 2-a]pyrimidine-6-carboxylate., Acta Cryst., E66(3), (2010), 762-763.
- John Coates, Interpretation of Infrared Spectra, A Practical Approach; Encyclopedia of Analytical Chemistry; R. A. Meyers (Ed.), pp. 10818-10837, John Wiley and Sons Ltd, Chichester, (2000).
- Gregory et al, NMR Chemical Shift of Trace Impurities; Organometallics; 29, (2010), 2176-2179.
- National Committee for Clinical Laboratory Standard. Reference Method for broth dilution antifungal susceptibility testing of yeasts; Approved standard M27A2; (2002), NCCLS, Wayne, PA.
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