In-vitro Hypoglycemic Activity of Barleria prionitis L.

Authors

  • Akshay R. Yadav  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
  • Manisha D. Rajput  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India
  • Kaustubh V. Gavali  Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, India
  • Dr. Shrinivas K. Mohite  Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India

Keywords:

Barleria prionitis, Glucose adsorption, Glucose diffusion, Hypoglycemic activity.

Abstract

Barleria prionitis is a shrub with yellow flowers and two flat seeds shielded with matted hairs, inhabit most parts of India. Various parts of the plant such as leaves, roots, aerial parts, flowers, and stems are used in the traditional system of medicine. Conventionally, various infusions are prepared using the plant parts and utilized for the treatment of different kinds of diseases. Owing to its incredible odontalgic property, it is extensively used in treating bleeding gums and toothache. Barleria prionitis plant extracts have been tested for their effects on glucose adsorption and diffusion. Adsorbed glucose is derived from the plant and glucose adsorption is greatly enhanced with an increase in glucose levels. The rate of diffusion from glucose in the kinetic amylolysis experimental model increased from 30 to 180 minutes, with plant extracts showing major inhibitory effects on glucose movement through the dialysis membrane to the external solution, in comparison to control. The results confirmed Barleria prionitis antidiabetic activity. By increasing glucose adsorption, growing glucose diffusion rate and at the cellular level, the hypoglycemic effect experienced by the extracts is mediated.

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Published

2020-10-30

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Research Articles

How to Cite

[1]
Akshay R. Yadav, Manisha D. Rajput, Kaustubh V. Gavali, Dr. Shrinivas K. Mohite, " In-vitro Hypoglycemic Activity of Barleria prionitis L., International Journal of Scientific Research in Chemistry(IJSRCH), ISSN : 2456-8457, Volume 5, Issue 5, pp.63-70, September-October-2020.