A Novel and Efficient Synthetic Route to (±)-Serinolamide A via Epoxide Ring Opening and Amide Coupling

Abstract

(±)-Serinolamide A, a serinol-derived fatty acid amide, plays an important role in cannabinoid receptor modulation. While existing synthetic approaches rely on direct amidation or enzymatic coupling, we present a new, efficient and modular synthetic route utilizing selective aziridine ring opening followed by amide bond formation with fatty acid chloride. This method offers enhanced regioselectivity, scalability, and adaptability to structural analogs.