Design and Synthesis of Eco-Friendly Heterocyclic Compounds Using Bio-Based Catalysts: A Sustainable Approach to Drug Discovery
Keywords:
Bio-based catalysts, Green chemistry, Heterocyclic compounds, Sustainable synthesis, Medicinal chemistry, Enzyme catalysis, Plant extracts, Eco-friendly methodology, Atom economy, Green metricsAbstract
Heterocyclic compounds represent a cornerstone of medicinal chemistry due to their diverse biological activities and prevalence in clinically approved pharmaceuticals. However, conventional synthetic routes for heterocycles often rely on hazardous reagents, toxic solvents, and energy-intensive conditions, posing significant environmental and safety concerns. In response to these challenges, this study explores a sustainable and eco-friendly synthetic approach utilizing bio-based catalysts—including plant extracts, microbial broths, and enzymatic systems—for the efficient construction of pharmacologically relevant heterocyclic scaffolds. The primary objectives were to (i) evaluate the catalytic efficiency and selectivity of various bio-derived catalysts in heterocycle formation, (ii) assess the green chemistry metrics associated with these methods, and (iii) confirm the structural integrity and pharmaceutical potential of the synthesized compounds. A range of nitrogen- and sulfur-containing heterocycles were synthesized under mild, aqueous, and solvent-free conditions, demonstrating high atom economy, low E-factors, and excellent reaction yields (78–93%). Spectroscopic techniques (FTIR, NMR, MS, UV–Vis) confirmed the structures of the final products, while green metrics and catalyst reusability studies emphasized the sustainability and scalability of the methodology. Mechanistic insights suggest that the catalytic activities stem from enzymatic or phytochemical-mediated pathways, providing regioselective and environmentally benign alternatives to traditional synthesis. This study highlights the promise of integrating bio-catalysis into heterocyclic drug synthesis, offering a green platform for early-stage pharmaceutical development and a valuable contribution to sustainable organic chemistry.
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