Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals based on Its Oxidation by Potassium Peroxydisulfate in the Presence of Ag(I) as a Catalyst
DOI:
https://doi.org/10.32628/IJSRCH24932Keywords:
L-Ascorbic Acid, Peroxydisulfate, Catalyst, Spectrophotometry, Pharmaceutical Preparations, Physico-Chemical CharacteristicsAbstract
New accurate, precise, and sensitive spectrophotometric method were developed for the assay of L-ascorbic acid in pharmaceutical preparations. The determination of L-ascorbic acid was based on its oxidation by potassium peroxydisulfate in the presence of Ag(I) as a catalyst. The molar absorptivity of the proposed method was found to be 8.61 · 103 L mol-1 cm-1 at 248 nm. Beer's law was obeyed in the concentration range of 0.46–20.0 μg mL–1. Other compounds commonly found in vitamin C and multivitamin products did not interfere with the determination of L-ascorbic acid. The proposed method was successfully applied for the determination of L-ascorbic acid in pharmaceutical formulations. The results obtained with the proposed method showed good agreement with those given by the titrimetric method using iodine.
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